DegronMD

Uniprot ID: O43526

Source protein: Potassium voltage-gated channel subfamily KQT member 2

Source gene: KCNQ2

Class: DEG_SPOP_SBC_1

Location: 713:717

E3 ligase: SPOP

DEGRON score: 0.8569

ASA_SCORE: 64.12

COIL: 0.8676

CONS_SCORE: 0.2048

DSS_SCORE: 0.7492

HELIX: 0.0922

FCONS_SCORE: 0.7783

RIG_SCORE: 0.5882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P709H	TCGA-2H-A9GH	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.A707T	TCGA-5P-A9JY	KIRP	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1667
p.A707T	TCGA-CM-6163	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1667
p.A707T	TCGA-X6-A8C6	SARC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1667
p.A707T	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.G716E	DO675	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7199
p.P725L	DO234230	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.R707H	DO234234	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.R707C	DO233662	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.D717N	DO220899	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6932
p.D717N	DO229453	SKCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6932
p.V715M	DO43739	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7208
p.A707V	SIDM02039	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.G727D	SIDM00537	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.P713L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7582
p.A706T	SIDM01617	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1389
p.S715C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7541
p.P704L	SIDM01750	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.S723L	ACH-000019	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1667
p.S723L	ACH-000028	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1667
p.V705M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1111
p.V705M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1111
p.V705M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with KCNQ2 mutations

All proteins holding degron of PPSTS