DegronMD - O14746(TERT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A163T	TCGA-44-8117	LUAD	TCGA	PPLY	ITCH	173:176	Mutation rewiring degron network	0.0556
p.A163T	DO24028	LUAD	ICGC	PPLY	ITCH	173:176	Mutation rewiring degron network	0.0556
p.A305V	TCGA-EO-A22R	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.2778
p.A305V	DO42713	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.2778
p.S311L	TCGA-FR-A726	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation altering degron motif	0.7667
p.S311L	DO220875	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation altering degron motif	0.7667
p.S311L	DO48665	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation altering degron motif	0.7667
p.P316L	TCGA-LK-A4O5	MESO	TCGA	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1944
p.A305T	DO50581	BOCA	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.2778
p.A167T	DO233120	GACA	ICGC	PPLY	ITCH	173:176	Mutation rewiring degron network	0.1667
p.P297Q	DO229031	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.0556
p.A305S	DO27326	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.2778
p.P164H	DO50721	ORCA	ICGC	PPLY	ITCH	173:176	Mutation rewiring degron network	0.0833
p.A184T	DO229268	THCA	ICGC	PPLY	ITCH	173:176	Mutation rewiring degron network	0.1111
p.V299L	SIDM00183	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1111
p.V299L	ACH-002154	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1111
p.V299L	LB647-SCLC	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1111
p.R301H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1667
p.R301H	ACH-000945	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	307:311	Mutation rewiring degron network	0.1667
p.S165R	ACH-001843	Bile Duct Cancer	CCLE	PPLY	ITCH	173:176	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TERT

UniProt ID: O14746

Entrez ID: 7015

Protein name: Telomerase reverse transcriptase (EC 2.7.7.49) (HEST2) (Telomerase catalytic subunit) (Telomerase-associated protein 2) (TP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TERT in