DegronMD

Uniprot ID: O14746

Source protein: Telomerase reverse transcriptase

Source gene: TERT

Class: DEG_SPOP_SBC_1

Location: 307:311

E3 ligase: SPOP

DEGRON score: 0.9923

ASA_SCORE: 73.72

COIL: 0.9274

CONS_SCORE: 0.3277

DSS_SCORE: 0.7478

HELIX: 0.0508

FCONS_SCORE: 1.0778

RIG_SCORE: 0.4743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A305V	TCGA-EO-A22R	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2778
p.A305V	DO42713	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.S311L	TCGA-FR-A726	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7667
p.S311L	DO220875	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7667
p.S311L	DO48665	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7667
p.P316L	TCGA-LK-A4O5	MESO	TCGA	PPSTS	DEG_SPOP_SBC_1	0.1944
p.A305T	DO50581	BOCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.P297Q	DO229031	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.A305S	DO27326	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.V299L	SIDM00183	Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.V299L	ACH-002154	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1111
p.V299L	LB647-SCLC	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.1111
p.R301H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.R301H	ACH-000945	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.1667

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.H752R (No)	GDSC	BIBR-1532	108.11
SIDM00683	PRAD\|prostate	p.R865C (No)	GDSC	BIBR-1532	20.518
SIDM00901	UCEC\|endometrium	p.D848G (No)	GDSC	BIBR-1532	78.345
SIDM00797	SKCM\|melanoma	p.T726P (No)	GDSC	BIBR-1532	60.717
SIDM00199	UNCLASSIFIED\|bone_other	p.A779T (No)	GDSC	BIBR-1532	98.897
SIDM01007	ALL\|lymphoblastic_leukemia	p.V741M (No)	GDSC	BIBR-1532	50.106
SIDM01088	UNCLASSIFIED\|endometrium	p.V639I (No)	GDSC	BIBR-1532	104.09
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R743Q (No)	GDSC	BIBR-1532	42.62
SIDM00003	SKCM\|melanoma	p.Q1024H (No)	GDSC	BIBR-1532	126.95
SIDM00887	MB\|medulloblastoma	p.R972H (No)	GDSC	BIBR-1532	64.393
SIDM01133	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P530L (No)	GDSC	BIBR-1532	42.097
SIDM00333	UCEC\|endometrium	p.A615V (No)	GDSC	BIBR-1532	171.57
SIDM00999	BLCA\|bladder	p.T878A (No)	GDSC	BIBR-1532	47.257
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.V898A (No)	GDSC	BIBR-1532	98.564
SIDM00216	COREAD\|large_intestine	p.A801T (No)	GDSC	BIBR-1532	147.29
SIDM00216	COREAD\|large_intestine	p.R743W (No)	GDSC	BIBR-1532	147.29
SIDM00216	COREAD\|large_intestine	p.Q506* (No)	GDSC	BIBR-1532	147.29
SIDM00596	UCEC\|endometrium	p.R521H (No)	GDSC	BIBR-1532	75.996
SIDM00660	COREAD\|large_intestine	p.V640M (No)	GDSC	BIBR-1532	103.3
SIDM00567	MB\|medulloblastoma	p.R938L (No)	GDSC	BIBR-1532	159.47
SIDM00783	COREAD\|large_intestine	p.E484K (No)	GDSC	BIBR-1532	57.361
SIDM00328	ESCA\|oesophagus	p.E1068K (No)	GDSC	BIBR-1532	351.56
SIDM00537	COREAD\|large_intestine	p.D807G (No)	GDSC	BIBR-1532	86.143
SIDM01062	BRCA\|breast	p.V746M (No)	GDSC	BIBR-1532	154.11
SIDM01062	BRCA\|breast	p.L520V (No)	GDSC	BIBR-1532	154.11

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with TERT mutations

All proteins holding degron of PPSTS