DegronMD - Q5T8I3(FAM102B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S158Y	TCGA-06-5416	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2778
p.S158Y	DO10880	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2778
p.C254Y	TCGA-AX-A2HD	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.C254Y	DO42608	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0556
p.T243A	TCGA-FI-A2D5	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.7139
p.T243A	DO41331	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.7139
p.D146H	TCGA-GV-A6ZA	BLCA	TCGA	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1667
p.D146H	DO49776	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1667
p.E231D	TCGA-X6-A7WB	SARC	TCGA	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.E231D	DO220314	SARC	ICGC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.V240L	DO228948	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation altering degron motif	0.6765
p.S144F	DO36556	READ	ICGC	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.E248K	SIDM00043	Head and Neck Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.E248K	ACH-002297	Head and Neck Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.E248K	PCI-4B	upper aerodigestive tract	COSMIC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.2222
p.P253S	SIDM00003	Melanoma	GDSC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.P253S	ACH-002159	Skin Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.P253S	M14	skin	COSMIC	VGSTS	DEG_SPOP_SBC_1	240:244	Mutation rewiring degron network	0.0833
p.T155I	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM102B

UniProt ID: Q5T8I3

Entrez ID: 284611

Protein name: Protein FAM102B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM102B in