DegronMD

Uniprot ID: Q5T8I3

Source protein: Protein FAM102B

Source gene: FAM102B

Class: DEG_SPOP_SBC_1

Location: 240:244

E3 ligase: SPOP

DEGRON score: 0.9943

ASA_SCORE: 69.9

COIL: 0.8528

CONS_SCORE: 0.4747

DSS_SCORE: 0.4563

HELIX: 0.0456

FCONS_SCORE: 1.1462

RIG_SCORE: 0.6202

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C254Y	TCGA-AX-A2HD	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.0556
p.C254Y	DO42608	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.T243A	TCGA-FI-A2D5	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.7139
p.T243A	DO41331	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7139
p.E231D	TCGA-X6-A7WB	SARC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.0833
p.E231D	DO220314	SARC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.0833
p.V240L	DO228948	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.6765
p.E248K	SIDM00043	Head and Neck Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.2222
p.E248K	ACH-002297	Head and Neck Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.2222
p.E248K	PCI-4B	upper_aerodigestive_tract	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.2222
p.P253S	SIDM00003	Melanoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0833
p.P253S	ACH-002159	Skin Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0833
p.P253S	M14	skin	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	329:333	VGSTS	SPOP	0.9983	More...
Q86SJ6	Desmoglein-4	DEG_SPOP_SBC_1	1017:1021	VGSTS	SPOP	0.9979	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	1043:1047	VGSTS	SPOP	0.9894	More...
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SPOP_SBC_1	450:454	VGSTS	SPOP	0.9993	More...
Q8NI99	Angiopoietin-related protein 6	DEG_SPOP_SBC_1	210:214	VGSTS	SPOP	0.5427	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	240:244	VGSTS	SPOP	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons