DegronMD - Q8NI99(ANGPTL6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P206Q	TCGA-67-3771	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2222
p.P206Q	DO25797	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2222
p.V210E	TCGA-AA-3666	COAD	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7693
p.V210E	DO9042	COAD	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7693
p.V210M	TCGA-D1-A103	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7208
p.V210M	DO42312	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.7208
p.D221N	TCGA-EO-A22R	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.D221N	DO42713	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.V210A	TCGA-FI-A2D5	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5825
p.V210A	DO41331	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation altering degron motif	0.5825
p.M219I	TCGA-IB-7651	PAAD	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.M219I	DO46657	PAAD	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.R208G	TCGA-XU-A92Z	THYM	TCGA	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2778
p.S217N	DO52444	COCA	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.25
p.M219T	DO233259	GACA	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.R208L	DO232017	ORCA	ICGC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2778
p.D221V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.D221V	ACH-001127	Leukemia	CCLE	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.D221V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389

Kaplan plot for ANGPTL6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANGPTL6

UniProt ID: Q8NI99

Entrez ID: 83854

Protein name: Angiopoietin-related protein 6 (Angiopoietin-like protein 6) (Angiopoietin-related growth factor) (Angiopoietin-related protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANGPTL6 in