DegronMD

Uniprot ID: Q8NI99

Source protein: Angiopoietin-related protein 6

Source gene: ANGPTL6

Class: DEG_SPOP_SBC_1

Location: 210:214

E3 ligase: SPOP

DEGRON score: 0.5427

ASA_SCORE: 62.78

COIL: 0.6736

CONS_SCORE: 0.3617

DSS_SCORE: 0.5507

HELIX: 0.2082

FCONS_SCORE: 0.9895

RIG_SCORE: 0.6406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P206Q	TCGA-67-3771	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.2222
p.P206Q	DO25797	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2222
p.V210E	TCGA-AA-3666	COAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.7693
p.V210E	DO9042	COAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7693
p.V210M	TCGA-D1-A103	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.7208
p.V210M	DO42312	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7208
p.D221N	TCGA-EO-A22R	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1389
p.D221N	DO42713	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1389
p.V210A	TCGA-FI-A2D5	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.5825
p.V210A	DO41331	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.5825
p.M219I	TCGA-IB-7651	PAAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1944
p.M219I	DO46657	PAAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.R208G	TCGA-XU-A92Z	THYM	TCGA	VGSTS	DEG_SPOP_SBC_1	0.2778
p.S217N	DO52444	COCA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.25
p.M219T	DO233259	GACA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.R208L	DO232017	ORCA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2778
p.D221V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VGSTS	DEG_SPOP_SBC_1	0.1389
p.D221V	ACH-001127	Leukemia	CCLE	VGSTS	DEG_SPOP_SBC_1	0.1389
p.D221V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	329:333	VGSTS	SPOP	0.9983	More...
Q86SJ6	Desmoglein-4	DEG_SPOP_SBC_1	1017:1021	VGSTS	SPOP	0.9979	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	1043:1047	VGSTS	SPOP	0.9894	More...
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SPOP_SBC_1	450:454	VGSTS	SPOP	0.9993	More...
Q8NI99	Angiopoietin-related protein 6	DEG_SPOP_SBC_1	210:214	VGSTS	SPOP	0.5427	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	240:244	VGSTS	SPOP	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons