DegronMD - Q99569(PKP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D400H	TCGA-55-A490	LUAD	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.0833
p.D400H	DO24596	LUAD	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.0833
p.R418S	TCGA-77-7142	LUSC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.2778
p.R418S	DO26462	LUSC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.2778
p.R270W	TCGA-A5-A0G2	UCEC	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.R270W	DO233699	GACA	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.R270W	DO41235	UCEC	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.R340C	TCGA-A6-3809	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340C	TCGA-FI-A2D0	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340C	DO8722	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340C	DO43891	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.D252N	TCGA-A8-A09N	BRCA	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.D252N	TCGA-D5-6928	COAD	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.D252N	DO5081	BRCA	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.D252N	DO7776	COAD	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.T412A	TCGA-AA-3984	COAD	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation altering degron motif	0.825
p.T412A	DO9002	COAD	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation altering degron motif	0.825
p.Y425C	TCGA-AP-A1DV	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation blocking phosphorylation signal	0.5278
p.Y425C	DO43186	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation blocking phosphorylation signal	0.5278
p.S82R	TCGA-AT-A5NU	KIRP	TCGA	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.8538
p.S82R	DO49729	KIRP	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.8538
p.S335L	TCGA-AX-A2HC	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.8778
p.S335L	DO41572	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.8778
p.A404V	TCGA-AX-A2HG	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1944
p.A404V	DO41337	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1944
p.G417E	TCGA-B5-A11E	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.3056
p.G417E	DO41644	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.3056
p.R340H	TCGA-BR-8680	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340H	DO47769	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.R340H	NCI-H2110	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.25
p.E85K	TCGA-C5-A8XK	CESC	TCGA	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.2778
p.E85K	DO49904	CESC	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.2778
p.A271T	TCGA-CD-A4MG	STAD	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.A271T	DO48009	STAD	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1389
p.S337P	TCGA-CG-5726	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7863
p.S337P	DO38483	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.7863
p.S422I	TCGA-CV-5430	HNSC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation blocking phosphorylation signal	0.6111
p.S422I	DO14270	HNSC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation blocking phosphorylation signal	0.6111
p.A79T	TCGA-D1-A17Q	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7139
p.A79T	DO41903	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7139
p.R426C	TCGA-D3-A8GM	SKCM	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.0556
p.R426C	DO50288	SKCM	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.0556
p.R402H	TCGA-DF-A2KZ	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1389
p.R402H	DO52409	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1389
p.D408G	TCGA-DI-A1BU	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.3056
p.D408G	DO42023	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.3056
p.P347Q	TCGA-EB-A24D	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.P347Q	DO37440	SKCM	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0556
p.P89S	TCGA-EE-A29E	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.1667
p.P89S	DO220895	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.1667
p.P89S	DO37831	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.1667
p.R402C	TCGA-EE-A2GC	SKCM	TCGA	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1389
p.R402C	DO37839	SKCM	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1389
p.S263F	TCGA-FR-A728	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7982
p.S263F	TCGA-W3-AA1R	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7982
p.S263F	DO48550	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7982
p.S263F	DO51275	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation altering degron motif	0.7982
p.P258S	TCGA-IH-A3EA	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.P258S	DO37667	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.P258L	TCGA-IH-A3EA	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.P258L	DO37667	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2778
p.A345T	TCGA-XF-A9T5	BLCA	TCGA	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1111
p.A345T	DO51925	BLCA	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1111
p.H1010R	TCGA-ZB-A96H	THYM	TCGA	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.2778
p.R254Q	DO223020	ESCA	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.S337F	DO233732	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.9093
p.W90L	DO228952	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation rewiring degron network	0.1389
p.L1018F	DO229028	LICA	ICGC	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.3056
p.R402L	DO229028	LICA	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1389
p.A404S	DO229026	LICA	ICGC	LHITPIYE	DEG_SCF_FBW7_2	409:416	Mutation rewiring degron network	0.1944
p.S259I	DO229034	LICA	ICGC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation blocking phosphorylation signal	0.75
p.A79S	DO229045	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.7588
p.G342W	DO25189	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1944
p.D1057E	SIDM00845	Burkitt's Lymphoma	GDSC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	SIDM00035	Thyroid Gland Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	SIDM00461	Acute Myeloid Leukemia	GDSC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	SIDM01519	Head and Neck Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	ACH-000037	Sarcoma	CCLE	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	ACH-000786	Lymphoma	CCLE	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	ACH-000992	Head and Neck Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	ACH-001067	Brain Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	Daudi	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.D1057E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556
p.A272T	SIDM01090	Colorectal Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.A272T	ACH-000943	Colon/Colorectal Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.A272T	RKO	large intestine	COSMIC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1111
p.T81A	SIDM00577	Neuroblastoma	GDSC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.825
p.T81A	ACH-001603	Neuroblastoma	CCLE	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.825
p.T81A	NH-12	autonomic ganglia	COSMIC	ASTSS	DEG_SPOP_SBC_1	79:83	Mutation altering degron motif	0.825
p.A268T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2222
p.A268T	ACH-002256	Leukemia	CCLE	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2222
p.A268T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.2222
p.T344I	SIDM00676	Bladder Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.T344I	ACH-000547	Bladder Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.T344I	HT-1197	urinary tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.1389
p.R270Q	SIDM00568	Gastric Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.R270Q	ACH-000247	Gastric Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.R270Q	OCUM-1	stomach	COSMIC	AYSST	DEG_SPOP_SBC_1	260:264	Mutation rewiring degron network	0.1667
p.D1004Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.1111
p.D1004Y	NCI-H838	lung	COSMIC	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.1111
p.P1027T	SIDM00167	Head and Neck Carcinoma	GDSC	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.0556
p.P1027T	ACH-000715	Head and Neck Cancer	CCLE	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation rewiring degron network	0.0556
p.S1047F	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation altering degron motif	0.7982
p.R324Q	ACH-000512	Myeloma	CCLE	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation rewiring degron network	0.0833
p.S336L	ACH-000961	Endometrial/Uterine Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	333:337	Mutation altering degron motif	0.8778
p.D1055E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.1111
p.D1055E	Daudi	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.1111
p.D1002Y	NCI-H838	lung	COSMIC	ITPVST	DEG_SCF_FBW7_1	1012:1017	Mutation substituting flanking lysine	0.1667
p.R1057H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	1043:1047	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKP4

UniProt ID: Q99569

Entrez ID: 8502

Protein name: Plakophilin-4 (p0071)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKP4 in