DegronMD

Uniprot ID: Q99569

Source protein: Plakophilin-4

Source gene: PKP4

Class: DEG_SCF_FBW7_1

Location: 1012:1017

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 54.5167

COIL: 0.7103

CONS_SCORE: 0.3617

DSS_SCORE: 0.3839

HELIX: 0.14

FCONS_SCORE: 0.8969

RIG_SCORE: 0.8075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1010R	TCGA-ZB-A96H	THYM	TCGA	ITPVST	DEG_SCF_FBW7_1	0.2778
p.L1018F	DO229028	LICA	ICGC	ITPVST	DEG_SCF_FBW7_1	0.3056
p.D1004Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	ITPVST	DEG_SCF_FBW7_1	0.1111
p.D1004Y	NCI-H838	lung	COSMIC	ITPVST	DEG_SCF_FBW7_1	0.1111
p.P1027T	SIDM00167	Head and Neck Carcinoma	GDSC	ITPVST	DEG_SCF_FBW7_1	0.0556
p.P1027T	ACH-000715	Head and Neck Cancer	CCLE	ITPVST	DEG_SCF_FBW7_1	0.0556
p.D1002Y	NCI-H838	lung	COSMIC	ITPVST	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99569	Plakophilin-4	DEG_SCF_FBW7_1	1012:1017	ITPVST	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons