DegronMD

Uniprot ID: Q99569

Source protein: Plakophilin-4

Source gene: PKP4

Class: DEG_SCF_FBW7_2

Location: 409:416

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 67.525

COIL: 0.8069

CONS_SCORE: 0.3243

DSS_SCORE: 0.3426

HELIX: 0.0688

FCONS_SCORE: 0.9445

RIG_SCORE: 0.7797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D400H	TCGA-55-A490	LUAD	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.0833
p.D400H	DO24596	LUAD	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.0833
p.R418S	TCGA-77-7142	LUSC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.2778
p.R418S	DO26462	LUSC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.2778
p.T412A	TCGA-AA-3984	COAD	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.825
p.T412A	DO9002	COAD	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.825
p.Y425C	TCGA-AP-A1DV	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.5278
p.Y425C	DO43186	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.5278
p.A404V	TCGA-AX-A2HG	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.1944
p.A404V	DO41337	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.1944
p.G417E	TCGA-B5-A11E	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.3056
p.G417E	DO41644	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.3056
p.S422I	TCGA-CV-5430	HNSC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.6111
p.S422I	DO14270	HNSC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.6111
p.R426C	TCGA-D3-A8GM	SKCM	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.0556
p.R426C	DO50288	SKCM	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.0556
p.R402H	TCGA-DF-A2KZ	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.1389
p.R402H	DO52409	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.1389
p.D408G	TCGA-DI-A1BU	UCEC	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.3056
p.D408G	DO42023	UCEC	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.3056
p.R402C	TCGA-EE-A2GC	SKCM	TCGA	LHITPIYE	DEG_SCF_FBW7_2	0.1389
p.R402C	DO37839	SKCM	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.1389
p.R402L	DO229028	LICA	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.1389
p.A404S	DO229026	LICA	ICGC	LHITPIYE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99569	Plakophilin-4	DEG_SCF_FBW7_2	409:416	LHITPIYE	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons