DegronMD

Uniprot ID: Q99569

Source protein: Plakophilin-4

Source gene: PKP4

Class: DEG_SPOP_SBC_1

Location: 260:264

E3 ligase: SPOP

DEGRON score: 0.9665

ASA_SCORE: 66.92

COIL: 0.8028

CONS_SCORE: 0.3119

DSS_SCORE: 0.5813

HELIX: 0.1218

FCONS_SCORE: 0.952

RIG_SCORE: 0.6678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R270W	TCGA-A5-A0G2	UCEC	TCGA	AYSST	DEG_SPOP_SBC_1	0.1667
p.R270W	DO233699	GACA	ICGC	AYSST	DEG_SPOP_SBC_1	0.1667
p.R270W	DO41235	UCEC	ICGC	AYSST	DEG_SPOP_SBC_1	0.1667
p.D252N	TCGA-A8-A09N	BRCA	TCGA	AYSST	DEG_SPOP_SBC_1	0.1111
p.D252N	TCGA-D5-6928	COAD	TCGA	AYSST	DEG_SPOP_SBC_1	0.1111
p.D252N	DO5081	BRCA	ICGC	AYSST	DEG_SPOP_SBC_1	0.1111
p.D252N	DO7776	COAD	ICGC	AYSST	DEG_SPOP_SBC_1	0.1111
p.A271T	TCGA-CD-A4MG	STAD	TCGA	AYSST	DEG_SPOP_SBC_1	0.1389
p.A271T	DO48009	STAD	ICGC	AYSST	DEG_SPOP_SBC_1	0.1389
p.S263F	TCGA-FR-A728	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.7982
p.S263F	TCGA-W3-AA1R	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.7982
p.S263F	DO48550	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.7982
p.S263F	DO51275	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.7982
p.P258S	TCGA-IH-A3EA	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.2778
p.P258S	DO37667	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.2778
p.P258L	TCGA-IH-A3EA	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.2778
p.P258L	DO37667	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.2778
p.R254Q	DO223020	ESCA	ICGC	AYSST	DEG_SPOP_SBC_1	0.1667
p.S259I	DO229034	LICA	ICGC	AYSST	DEG_SPOP_SBC_1	0.75
p.A272T	SIDM01090	Colorectal Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.1111
p.A272T	ACH-000943	Colon/Colorectal Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.1111
p.A272T	RKO	large_intestine	COSMIC	AYSST	DEG_SPOP_SBC_1	0.1111
p.A268T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	AYSST	DEG_SPOP_SBC_1	0.2222
p.A268T	ACH-002256	Leukemia	CCLE	AYSST	DEG_SPOP_SBC_1	0.2222
p.A268T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	AYSST	DEG_SPOP_SBC_1	0.2222
p.R270Q	SIDM00568	Gastric Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.1667
p.R270Q	ACH-000247	Gastric Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.1667
p.R270Q	OCUM-1	stomach	COSMIC	AYSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3422:3426	AYSST	SPOP	0.7097	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	260:264	AYSST	SPOP	0.9665	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	165:169	AYSST	SPOP	0.792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AYSST

Degron related mutations and impact score

Drug responses associated with PKP4 mutations

All proteins holding degron of AYSST