DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 3422:3426

E3 ligase: SPOP

DEGRON score: 0.7097

ASA_SCORE: 84.66

COIL: 0.816

CONS_SCORE: 0

DSS_SCORE: 0.5073

HELIX: 0.035

FCONS_SCORE: 0

RIG_SCORE: 0.6696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3428Y	TCGA-05-4418	LUAD	TCGA	AYSST	DEG_SPOP_SBC_1	0.2778
p.S3428Y	DO23814	LUAD	ICGC	AYSST	DEG_SPOP_SBC_1	0.2778
p.S3428Y	SIDM00193	Colorectal Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.2778
p.S3428Y	ACH-000991	Colon/Colorectal Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.2778
p.S3428Y	SNU-81	large_intestine	COSMIC	AYSST	DEG_SPOP_SBC_1	0.2778
p.A3422S	TCGA-17-Z030	LUAD	TCGA	AYSST	DEG_SPOP_SBC_1	0.7588
p.S3428C	TCGA-37-3792	LUSC	TCGA	AYSST	DEG_SPOP_SBC_1	0.2778
p.S3428C	DO27192	LUSC	ICGC	AYSST	DEG_SPOP_SBC_1	0.2778
p.D3431N	TCGA-EE-A2GN	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.1944
p.D3431N	DO37896	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.G3435E	TCGA-ER-A194	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.0833
p.G3435E	DO47646	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.0833
p.R3417Q	DO227999	COCA	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.R3417Q	DO229003	COCA	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.R3417Q	DO229489	LAML	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.R3417Q	DO229505	LAML	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.R3417Q	DO231091	LUSC	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.R3417Q	DO231120	LUSC	ICGC	AYSST	DEG_SPOP_SBC_1	0.1944
p.T3433I	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.1389
p.T3433I	ACH-000481	Lung Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.1389
p.T3433I	NCI-H2170	lung	COSMIC	AYSST	DEG_SPOP_SBC_1	0.1389
p.E3421K	ACH-000458	Skin Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3422:3426	AYSST	SPOP	0.7097	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	260:264	AYSST	SPOP	0.9665	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	165:169	AYSST	SPOP	0.792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons