DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SPOP_SBC_1

Location: 165:169

E3 ligase: SPOP

DEGRON score: 0.792

ASA_SCORE: 86.02

COIL: 0.8774

CONS_SCORE: 0.5679

DSS_SCORE: 0.4485

HELIX: 0.0816

FCONS_SCORE: 0.9712

RIG_SCORE: 0.7331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y166C	TCGA-B5-A11E	UCEC	TCGA	AYSST	DEG_SPOP_SBC_1	0.5976
p.Y166C	DO41644	UCEC	ICGC	AYSST	DEG_SPOP_SBC_1	0.5976
p.S159F	TCGA-BR-A4QL	STAD	TCGA	AYSST	DEG_SPOP_SBC_1	0.1667
p.S159F	DO38723	STAD	ICGC	AYSST	DEG_SPOP_SBC_1	0.1667
p.S159F	SIDM01000	Melanoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.1667
p.S159F	ACH-000304	Skin Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.1667
p.S159F	ACH-000726	Esophageal Cancer	CCLE	AYSST	DEG_SPOP_SBC_1	0.1667
p.S159F	WM-115	skin	COSMIC	AYSST	DEG_SPOP_SBC_1	0.1667
p.A165V	TCGA-EE-A2MC	SKCM	TCGA	AYSST	DEG_SPOP_SBC_1	0.5825
p.A165V	DO222426	MELA	ICGC	AYSST	DEG_SPOP_SBC_1	0.5825
p.A165V	DO37559	SKCM	ICGC	AYSST	DEG_SPOP_SBC_1	0.5825
p.S167I	DO222762	COCA	ICGC	AYSST	DEG_SPOP_SBC_1	0.7341
p.S173I	DO229045	LICA	ICGC	AYSST	DEG_SPOP_SBC_1	0.2222
p.A155T	SIDM00845	Burkitt's Lymphoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.0556
p.A155T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AYSST	DEG_SPOP_SBC_1	0.0556
p.S159A	SIDM00845	Burkitt's Lymphoma	GDSC	AYSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3422:3426	AYSST	SPOP	0.7097	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	260:264	AYSST	SPOP	0.9665	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	165:169	AYSST	SPOP	0.792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons