DegronMD

Uniprot ID: Q99569

Source protein: Plakophilin-4

Source gene: PKP4

Class: DEG_SPOP_SBC_1

Location: 1043:1047

E3 ligase: SPOP

DEGRON score: 0.9894

ASA_SCORE: 72.02

COIL: 0.9126

CONS_SCORE: 0.3737

DSS_SCORE: 0.5595

HELIX: 0.0478

FCONS_SCORE: 1.0117

RIG_SCORE: 0.6064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1057E	SIDM00845	Burkitt's Lymphoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	SIDM00035	Thyroid Gland Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	SIDM00461	Acute Myeloid Leukemia	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	SIDM01519	Head and Neck Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	ACH-000037	Sarcoma	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	ACH-000786	Lymphoma	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	ACH-000992	Head and Neck Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	ACH-001067	Brain Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.D1057E	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.S1047F	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.7982
p.D1055E	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1111
p.D1055E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1111
p.R1057H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	329:333	VGSTS	SPOP	0.9983	More...
Q86SJ6	Desmoglein-4	DEG_SPOP_SBC_1	1017:1021	VGSTS	SPOP	0.9979	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	1043:1047	VGSTS	SPOP	0.9894	More...
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SPOP_SBC_1	450:454	VGSTS	SPOP	0.9993	More...
Q8NI99	Angiopoietin-related protein 6	DEG_SPOP_SBC_1	210:214	VGSTS	SPOP	0.5427	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	240:244	VGSTS	SPOP	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons