DegronMD

Uniprot ID: Q86SJ6

Source protein: Desmoglein-4

Source gene: DSG4

Class: DEG_SPOP_SBC_1

Location: 1017:1021

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 78.54

COIL: 0.7678

CONS_SCORE: 0.4458

DSS_SCORE: 0.614

HELIX: 0.0224

FCONS_SCORE: 1.1587

RIG_SCORE: 0.6417

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1018S	TCGA-55-8092	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.6752
p.P1018S	DO26220	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.6752
p.Q1024K	TCGA-61-1895	OV	TCGA	VGSTS	DEG_SPOP_SBC_1	0.25
p.Q1024K	DO30020	OV	ICGC	VGSTS	DEG_SPOP_SBC_1	0.25
p.G1017R	TCGA-73-4670	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.7568
p.G1017R	TCGA-DR-A0ZM	CESC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.7568
p.G1017R	DO6254	CESC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7568
p.G1017R	DO25350	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7568
p.M1026I	TCGA-95-7947	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1944
p.M1026I	DO26404	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.P1028T	TCGA-AP-A059	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1389
p.P1028T	DO41361	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1389
p.M1026T	TCGA-AX-A2HG	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1944
p.M1026T	DO41337	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.M1025I	TCGA-CA-6718	COAD	TCGA	VGSTS	DEG_SPOP_SBC_1	0.2222
p.M1025I	DO7801	COAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2222
p.M1025I	DO222415	MELA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2222
p.G1007E	TCGA-WE-A8ZO	SKCM	TCGA	VGSTS	DEG_SPOP_SBC_1	0.0556
p.G1007E	DO51286	SKCM	ICGC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.V1009L	DO229018	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1111
p.P1031S	SIDM00683	Prostate Carcinoma	GDSC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.P1031S	LNCaP-Clone-FGC	prostate	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.R1031Q	ACH-000225	Gastric Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.R1031Q	ACH-000999	Colon/Colorectal Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0556
p.R1031Q	SNU-1040	large_intestine	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.R1031Q	ECC12	stomach	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.G1014S	ACH-000899	Skin Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.25
p.P1022S	ACH-000916	Lung Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.3056
p.P1022S	NCI-H1573	lung	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.3056
p.P1012S	ACH-000977	lymph_node	CCLE	VGSTS	DEG_SPOP_SBC_1	0.1944
p.P1012S	LNCaP-Clone-FGC	prostate	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.V1029A	ACH-001518	Endometrial/Uterine Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.1111
p.S1008G	ACH-002287	Colon/Colorectal Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	0.0833
p.S1008G	NCI-H630	large_intestine	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.0833
p.S1027G	NCI-H630	large_intestine	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	329:333	VGSTS	SPOP	0.9983	More...
Q86SJ6	Desmoglein-4	DEG_SPOP_SBC_1	1017:1021	VGSTS	SPOP	0.9979	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	1043:1047	VGSTS	SPOP	0.9894	More...
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SPOP_SBC_1	450:454	VGSTS	SPOP	0.9993	More...
Q8NI99	Angiopoietin-related protein 6	DEG_SPOP_SBC_1	210:214	VGSTS	SPOP	0.5427	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	240:244	VGSTS	SPOP	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSTS

Degron related mutations and impact score

Drug responses associated with DSG4 mutations

All proteins holding degron of VGSTS