DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VGSTS
Uniprot ID:
Q15637
Source protein:
Splicing factor 1
Source gene:
SF1
Class:
DEG_SPOP_SBC_1
Location:
329:333
E3 ligase:
SPOP
DEGRON score:
0.9983
ASA_SCORE:
71.64
COIL:
0.954
CONS_SCORE:
0.2541
DSS_SCORE:
0.6217
HELIX:
0.0202
FCONS_SCORE:
0.7787
RIG_SCORE:
0.5379
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L328F
TCGA-86-8073
LUAD
TCGA
VGSTS
DEG_SPOP_SBC_1
0.3056
p.L328F
TCGA-DK-A1AC
BLCA
TCGA
VGSTS
DEG_SPOP_SBC_1
0.3056
p.H329Y
TCGA-99-8032
LUAD
TCGA
VGSTS
DEG_SPOP_SBC_1
0.7229
p.H329Y
DO23765
LUAD
ICGC
VGSTS
DEG_SPOP_SBC_1
0.7229
p.L331P
TCGA-AP-A1DK
UCEC
TCGA
VGSTS
DEG_SPOP_SBC_1
0.7582
p.D325Y
TCGA-AX-A1CE
UCEC
TCGA
VGSTS
DEG_SPOP_SBC_1
0.2222
p.D325Y
DO42280
UCEC
ICGC
VGSTS
DEG_SPOP_SBC_1
0.2222
p.D325N
TCGA-E7-A7DV
BLCA
TCGA
VGSTS
DEG_SPOP_SBC_1
0.2222
p.D325N
DO48583
BLCA
ICGC
VGSTS
DEG_SPOP_SBC_1
0.2222
p.G323E
TCGA-E7-A7DV
BLCA
TCGA
VGSTS
DEG_SPOP_SBC_1
0.1667
p.G323R
TCGA-E7-A7DV
BLCA
TCGA
VGSTS
DEG_SPOP_SBC_1
0.1667
p.A330D
DO228974
LICA
ICGC
VGSTS
DEG_SPOP_SBC_1
0.7793
p.T333N
DO229031
LICA
ICGC
VGSTS
DEG_SPOP_SBC_1
0.7055
p.A324T
ACH-000942
Leukemia
CCLE
VGSTS
DEG_SPOP_SBC_1
0.1944
p.A334T
Daudi
haematopoietic_and_lymphoid_tissue
COSMIC
VGSTS
DEG_SPOP_SBC_1
0.3056
p.P330L
HC-1
haematopoietic_and_lymphoid_tissue
COSMIC
VGSTS
DEG_SPOP_SBC_1
0.7582
p.P326S
Mewo
skin
COSMIC
VGSTS
DEG_SPOP_SBC_1
0.25
Drug responses associated with SF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q15637
Splicing factor 1
DEG_SPOP_SBC_1
329:333
VGSTS
SPOP
0.9983
More...
Q86SJ6
Desmoglein-4
DEG_SPOP_SBC_1
1017:1021
VGSTS
SPOP
0.9979
More...
Q99569
Plakophilin-4
DEG_SPOP_SBC_1
1043:1047
VGSTS
SPOP
0.9894
More...
Q99640
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
DEG_SPOP_SBC_1
450:454
VGSTS
SPOP
0.9993
More...
Q8NI99
Angiopoietin-related protein 6
DEG_SPOP_SBC_1
210:214
VGSTS
SPOP
0.5427
More...
Q5T8I3
Protein FAM102B
DEG_SPOP_SBC_1
240:244
VGSTS
SPOP
0.9943
More...