DegronMD - Q86SJ6(DSG4)

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.

GO - Biological processes (BP): BMP signaling pathway [GO:0030509]; cell-cell adhesion [GO:0098609]; hair follicle development [GO:0001942]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte differentiation [GO:0030216]

GO - Molecular function (MF): calcium ion binding [GO:0005509]

GO - Cellular component (CC): cell-cell junction [GO:0005911]; cornified envelope [GO:0001533]; desmosome [GO:0030057]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1017R	TCGA-73-4670	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.7568
p.G1017R	TCGA-DR-A0ZM	CESC	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.7568
p.G1017R	DO6254	CESC	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.7568
p.G1017R	DO25350	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.7568
p.P1018S	TCGA-55-8092	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.6752
p.P1018S	DO26220	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.6752
p.P1022S	ACH-000916	Lung Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.3056
p.P1022S	NCI-H1573	lung	COSMIC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.3056
p.Q1024K	TCGA-61-1895	OV	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.25
p.Q1024K	DO30020	OV	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.25
p.G1014S	ACH-000899	Skin Cancer	CCLE	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.25
p.M1025I	TCGA-CA-6718	COAD	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2222
p.M1025I	DO7801	COAD	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2222
p.M1025I	DO222415	MELA	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2222
p.M1026I	TCGA-95-7947	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.M1026I	DO26404	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.M1026T	TCGA-AX-A2HG	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.M1026T	DO41337	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.P1012S	ACH-000977	lymph node	CCLE	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.P1012S	LNCaP-Clone-FGC	prostate	COSMIC	VGSTS	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 35 entries

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Kaplan plot for DSG4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSG4

UniProt ID: Q86SJ6

Entrez ID: 147409

Protein name: Desmoglein-4 (Cadherin family member 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSG4 in