DegronMD

Uniprot ID: Q99640

Source protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Source gene: PKMYT1

Class: DEG_SPOP_SBC_1

Location: 450:454

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 76.98

COIL: 0.9484

CONS_SCORE: 0.3619

DSS_SCORE: 0.5364

HELIX: 0.0284

FCONS_SCORE: 0.8819

RIG_SCORE: 0.6242

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R459S	TCGA-A5-A0G1	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	0.1944
p.L459I	DO229034	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.H440N	DO229036	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.H440N	DO229045	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.0556
p.S445F	DO220898	MELA	ICGC	VGSTS	DEG_SPOP_SBC_1	0.1944
p.A456V	DO38201	STAD	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2778
p.A456D	DO41674	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.2778
p.R450S	DO42472	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	0.7427
p.P442H	KM12	large_intestine	COSMIC	VGSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	329:333	VGSTS	SPOP	0.9983	More...
Q86SJ6	Desmoglein-4	DEG_SPOP_SBC_1	1017:1021	VGSTS	SPOP	0.9979	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	1043:1047	VGSTS	SPOP	0.9894	More...
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SPOP_SBC_1	450:454	VGSTS	SPOP	0.9993	More...
Q8NI99	Angiopoietin-related protein 6	DEG_SPOP_SBC_1	210:214	VGSTS	SPOP	0.5427	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	240:244	VGSTS	SPOP	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons