DegronMD - Q99640(PKMYT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R459S	TCGA-A5-A0G1	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1944
p.P413Q	TCGA-CN-5374	HNSC	TCGA	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation altering degron motif	0.7035
p.W403G	TCGA-D7-A6EY	STAD	TCGA	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.1667
p.P481L	TCGA-EE-A3AG	SKCM	TCGA	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1111
p.T499I	TCGA-IB-7651	PAAD	TCGA	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.1944
p.P417L	TCGA-L5-A8NE	ESCA	TCGA	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.R494T	DO6144	BRCA	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.7876
p.R503Q	DO222971	BTCA	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.R503Q	DO229221	THCA	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.R503Q	DO41199	UCEC	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.R503W	DO49929	CESC	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.S416N	DO222501	COCA	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation altering degron motif	0.818
p.P479H	DO228542	GACA	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation blocking phosphorylation signal	0.5
p.P404Q	DO15430	HNSC	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.1944
p.P404Q	DO25847	LUAD	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.1944
p.L418F	DO22237	LGG	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.2778
p.L459I	DO229034	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1944
p.H440N	DO229036	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0556
p.H440N	DO229045	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.0556
p.G406A	DO25847	LUAD	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.25
p.S445F	DO220898	MELA	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1944
p.T490I	DO46657	PAAD	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.7078
p.A456V	DO38201	STAD	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.A456D	DO41674	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.2778
p.T480I	DO43891	UCEC	ICGC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.0833
p.R450S	DO42472	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation altering degron motif	0.7427
p.L418I	DO42713	UCEC	ICGC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.2778
p.R486W	SIDM00578	Neuroblastoma	GDSC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.R486W	ACH-000804	Neuroblastoma	CCLE	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.R486W	NB1	autonomic ganglia	COSMIC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.25
p.P498L	SIDM00333	Endometrial Carcinoma	GDSC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2222
p.P498L	ACH-000988	Endometrial/Uterine Cancer	CCLE	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2222
p.P498L	MFE-319	endometrium	COSMIC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation rewiring degron network	0.2222
p.P417R	SIDM00203	Ewing's Sarcoma	GDSC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.P417R	ACH-002111	Bone Cancer	CCLE	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.G408D	SIDM00018	Acute Myeloid Leukemia	GDSC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.G408D	ACH-000498	Leukemia	CCLE	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.G408D	KO52	haematopoietic and lymphoid tissue	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.D423E	JHOS-4	ovary	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.1389
p.R417W	NB1	autonomic ganglia	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056
p.P489L	MFE-319	endometrium	COSMIC	LSLFED	LIG_APCC_ABBA_1	489:494	Mutation altering degron motif	0.7582
p.P442H	KM12	large intestine	COSMIC	VGSTS	DEG_SPOP_SBC_1	450:454	Mutation rewiring degron network	0.1111
p.G399D	KO52	haematopoietic and lymphoid tissue	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.0556
p.R408W	BT-474	breast	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	409:416	Mutation rewiring degron network	0.3056

Kaplan plot for PKMYT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKMYT1

UniProt ID: Q99640

Entrez ID: 9088

Protein name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKMYT1 in