DegronMD

Uniprot ID: Q99640

Source protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Source gene: PKMYT1

Class: LIG_APCC_ABBA_1

Location: 489:494

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9847

ASA_SCORE: 66.05

COIL: 0.1582

CONS_SCORE: 0.4751

DSS_SCORE: 0.5973

HELIX: 0.8203

FCONS_SCORE: 1.2003

RIG_SCORE: 0.77

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P481L	TCGA-EE-A3AG	SKCM	TCGA	LSLFED	LIG_APCC_ABBA_1	0.1111
p.T499I	TCGA-IB-7651	PAAD	TCGA	LSLFED	LIG_APCC_ABBA_1	0.1944
p.R494T	DO6144	BRCA	ICGC	LSLFED	LIG_APCC_ABBA_1	0.7876
p.R503Q	DO222971	BTCA	ICGC	LSLFED	LIG_APCC_ABBA_1	0.0833
p.R503Q	DO229221	THCA	ICGC	LSLFED	LIG_APCC_ABBA_1	0.0833
p.R503Q	DO41199	UCEC	ICGC	LSLFED	LIG_APCC_ABBA_1	0.0833
p.R503W	DO49929	CESC	ICGC	LSLFED	LIG_APCC_ABBA_1	0.0833
p.P479H	DO228542	GACA	ICGC	LSLFED	LIG_APCC_ABBA_1	0.5
p.T490I	DO46657	PAAD	ICGC	LSLFED	LIG_APCC_ABBA_1	0.7078
p.T480I	DO43891	UCEC	ICGC	LSLFED	LIG_APCC_ABBA_1	0.0833
p.R486W	SIDM00578	Neuroblastoma	GDSC	LSLFED	LIG_APCC_ABBA_1	0.25
p.R486W	ACH-000804	Neuroblastoma	CCLE	LSLFED	LIG_APCC_ABBA_1	0.25
p.R486W	NB1	autonomic_ganglia	COSMIC	LSLFED	LIG_APCC_ABBA_1	0.25
p.P498L	SIDM00333	Endometrial Carcinoma	GDSC	LSLFED	LIG_APCC_ABBA_1	0.2222
p.P498L	ACH-000988	Endometrial/Uterine Cancer	CCLE	LSLFED	LIG_APCC_ABBA_1	0.2222
p.P498L	MFE-319	endometrium	COSMIC	LSLFED	LIG_APCC_ABBA_1	0.2222
p.P489L	MFE-319	endometrium	COSMIC	LSLFED	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	LIG_APCC_ABBA_1	489:494	LSLFED	APC,CDC20,FZR1	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons