DegronMD

Uniprot ID: Q99640

Source protein: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Source gene: PKMYT1

Class: DEG_SCF_FBW7_1

Location: 409:416

E3 ligase: FBXW7

DEGRON score: 0.9847

ASA_SCORE: 79.375

COIL: 0.971

CONS_SCORE: 0.4448

DSS_SCORE: 0.4649

HELIX: 0.0116

FCONS_SCORE: 1.1435

RIG_SCORE: 0.5852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P413Q	TCGA-CN-5374	HNSC	TCGA	PPATPPGS	DEG_SCF_FBW7_1	0.7035
p.W403G	TCGA-D7-A6EY	STAD	TCGA	PPATPPGS	DEG_SCF_FBW7_1	0.1667
p.P417L	TCGA-L5-A8NE	ESCA	TCGA	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.S416N	DO222501	COCA	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.818
p.P404Q	DO15430	HNSC	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.1944
p.P404Q	DO25847	LUAD	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.1944
p.L418F	DO22237	LGG	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.2778
p.G406A	DO25847	LUAD	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.25
p.L418I	DO42713	UCEC	ICGC	PPATPPGS	DEG_SCF_FBW7_1	0.2778
p.P417R	SIDM00203	Ewing's Sarcoma	GDSC	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.P417R	ACH-002111	Bone Cancer	CCLE	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.G408D	SIDM00018	Acute Myeloid Leukemia	GDSC	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.G408D	ACH-000498	Leukemia	CCLE	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.G408D	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.D423E	JHOS-4	ovary	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	0.1389
p.R417W	NB1	autonomic_ganglia	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	0.3056
p.G399D	KO52	haematopoietic_and_lymphoid_tissue	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	0.0556
p.R408W	BT-474	breast	COSMIC	PPATPPGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	DEG_SCF_FBW7_1	409:416	PPATPPGS	FBXW7	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons