DegronMD - Q15637(SF1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P523S	TCGA-66-2763	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1389
p.R348K	TCGA-77-6845	LUSC	TCGA	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1667
p.L328F	TCGA-86-8073	LUAD	TCGA	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1389
p.L328F	TCGA-86-8073	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.L328F	TCGA-DK-A1AC	BLCA	TCGA	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1389
p.L328F	TCGA-DK-A1AC	BLCA	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.H329Y	TCGA-99-8032	LUAD	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7229
p.H329Y	DO23765	LUAD	ICGC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7229
p.L331P	TCGA-AP-A1DK	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7582
p.D325Y	TCGA-AX-A1CE	UCEC	TCGA	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.D325Y	TCGA-AX-A1CE	UCEC	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.D325Y	DO42280	UCEC	ICGC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.D325Y	DO42280	UCEC	ICGC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.A466T	TCGA-CK-5916	COAD	TCGA	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1111
p.D325N	TCGA-E7-A7DV	BLCA	TCGA	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.D325N	TCGA-E7-A7DV	BLCA	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.D325N	DO48583	BLCA	ICGC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.D325N	DO48583	BLCA	ICGC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.2222
p.G323E	TCGA-E7-A7DV	BLCA	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.G323R	TCGA-E7-A7DV	BLCA	TCGA	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1667
p.P525S	TCGA-EE-A181	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.0833
p.P519S	TCGA-FW-A3R5	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.25
p.P519S	DO37406	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.25
p.P452L	DO2836	BRCA	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7582
p.A514T	DO51734	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7139
p.G443D	DO8938	COAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1111
p.G443D	DO43506	UCEC	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1111
p.A341T	DO8786	COAD	ICGC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.6028
p.K468E	DO15855	HNSC	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.0556
p.T504M	DO22237	LGG	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1111
p.A330D	DO228974	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7793
p.P515T	DO229031	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7031
p.T333N	DO229031	LICA	ICGC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7055
p.G458W	DO25189	LUAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7825
p.G511S	DO45323	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.3056
p.A526T	DO223709	PAAD	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.0556
p.G513W	DO37835	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7825
p.G513W	DO38016	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7825
p.S514F	DO51267	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7982
p.P457L	DO38214	STAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7582
p.G511V	DO229240	THCA	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.3056
p.T503M	DO41871	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.0833
p.T508M	DO43891	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.2222
p.P451S	SIDM00545	Melanoma	GDSC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.6752
p.P451S	Mewo	skin	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.6752
p.G506S	SIDM00217	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.G506S	SNU-1040	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.M447V	ACH-000278	Ovarian Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.2222
p.M452L	ACH-000492	Leukemia	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.711
p.G461W	ACH-000878	Lung Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation blocking phosphorylation signal	0.6944
p.G461W	HCC-15	lung	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation blocking phosphorylation signal	0.6944
p.A324T	ACH-000942	Leukemia	CCLE	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.1944
p.Q519R	ACH-000992	Head and Neck Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.25
p.P454L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7582
p.P454L	ACH-002096	Skin Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7582
p.P454L	ACH-002346	Non-Cancerous	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7582
p.A523V	ACH-000995	Leukemia	CCLE	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1389
p.S515N	ACH-001345	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7069
p.S515N	GP5d	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7069
p.P512S	ACH-002396	Bone Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.6752
p.P512S	Sarc9371	bone	COSMIC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.6752
p.S513F	Sarc9371	bone	COSMIC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation altering degron motif	0.7982
p.S450L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation blocking phosphorylation signal	0.75
p.A456T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7139
p.A334T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.3056
p.A334T	Daudi	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.3056
p.P330L	HC-1	haematopoietic and lymphoid tissue	COSMIC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation altering degron motif	0.7582
p.P326S	Mewo	skin	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0833
p.P326S	Mewo	skin	COSMIC	VGSTS	DEG_SPOP_SBC_1	329:333	Mutation rewiring degron network	0.25
p.Y522H	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	512:516	Mutation rewiring degron network	0.1667
p.S350N	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SF1

UniProt ID: Q15637

Entrez ID: 7536

Protein name: Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SF1 in