DegronMD

Uniprot ID: Q15637

Source protein: Splicing factor 1

Source gene: SF1

Class: DEG_SCF_FBW7_1

Location: 335:342

E3 ligase: FBXW7

DEGRON score: 0.9806

ASA_SCORE: 77.425

COIL: 0.87

CONS_SCORE: 0.2447

DSS_SCORE: 0.6603

HELIX: 0.111

FCONS_SCORE: 0.8733

RIG_SCORE: 0.6026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R348K	TCGA-77-6845	LUSC	TCGA	PATTPLAS	DEG_SCF_FBW7_1	0.1667
p.L328F	TCGA-86-8073	LUAD	TCGA	PATTPLAS	DEG_SCF_FBW7_1	0.1389
p.L328F	TCGA-DK-A1AC	BLCA	TCGA	PATTPLAS	DEG_SCF_FBW7_1	0.1389
p.D325Y	TCGA-AX-A1CE	UCEC	TCGA	PATTPLAS	DEG_SCF_FBW7_1	0.0556
p.D325Y	DO42280	UCEC	ICGC	PATTPLAS	DEG_SCF_FBW7_1	0.0556
p.D325N	TCGA-E7-A7DV	BLCA	TCGA	PATTPLAS	DEG_SCF_FBW7_1	0.0556
p.D325N	DO48583	BLCA	ICGC	PATTPLAS	DEG_SCF_FBW7_1	0.0556
p.A341T	DO8786	COAD	ICGC	PATTPLAS	DEG_SCF_FBW7_1	0.6028
p.A334T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	0.3056
p.P326S	Mewo	skin	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	0.0833
p.S350N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPLAS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SCF_FBW7_1	335:342	PATTPLAS	FBXW7	0.9806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons