DegronMD

Uniprot ID: Q15637

Source protein: Splicing factor 1

Source gene: SF1

Class: DEG_SCF_FBW7_1

Location: 451:458

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 55.525

COIL: 0.9104

CONS_SCORE: 0.2186

DSS_SCORE: 0.6728

HELIX: 0.0373

FCONS_SCORE: 0.993

RIG_SCORE: 0.5928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A466T	TCGA-CK-5916	COAD	TCGA	LGSTPVGS	DEG_SCF_FBW7_1	0.1111
p.P452L	DO2836	BRCA	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.7582
p.G443D	DO8938	COAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.1111
p.G443D	DO43506	UCEC	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.1111
p.K468E	DO15855	HNSC	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.0556
p.G458W	DO25189	LUAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.7825
p.P457L	DO38214	STAD	ICGC	LGSTPVGS	DEG_SCF_FBW7_1	0.7582
p.P451S	SIDM00545	Melanoma	GDSC	LGSTPVGS	DEG_SCF_FBW7_1	0.6752
p.P451S	Mewo	skin	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	0.6752
p.M447V	ACH-000278	Ovarian Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.2222
p.M452L	ACH-000492	Leukemia	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.711
p.G461W	ACH-000878	Lung Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.6944
p.G461W	HCC-15	lung	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	0.6944
p.P454L	ACH-000994	Endometrial/Uterine Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.7582
p.P454L	ACH-002096	Skin Cancer	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.7582
p.P454L	ACH-002346	Non-Cancerous	CCLE	LGSTPVGS	DEG_SCF_FBW7_1	0.7582
p.S450L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	0.75
p.A456T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LGSTPVGS	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15637	Splicing factor 1	DEG_SCF_FBW7_1	451:458	LGSTPVGS	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons