DegronMD - Q12830(BPTF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2483P	TCGA-19-5956	GBM	TCGA	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.0556
p.T2483P	DO13863	GBM	ICGC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.0556
p.T1987I	TCGA-50-6592	LUAD	TCGA	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.1389
p.T1987I	DO23742	LUAD	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.1389
p.I710M	TCGA-55-8208	LUAD	TCGA	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1111
p.I710M	DO51192	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1111
p.Q2240H	TCGA-61-1914	OV	TCGA	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.0556
p.Q2240H	DO28105	OV	ICGC	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.0556
p.R723P	TCGA-A5-A0GE	UCEC	TCGA	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.R723P	DO42424	UCEC	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.R2065T	TCGA-AC-A23H	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	TCGA-HU-A4GU	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	DO2401	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	DO47849	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.V2001I	TCGA-AJ-A3EL	UCEC	TCGA	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation altering degron motif	0.7076
p.V2001I	TCGA-XD-AAUI	PAAD	TCGA	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation altering degron motif	0.7076
p.V2001I	DO51722	PAAD	ICGC	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation altering degron motif	0.7076
p.V2001I	DO41542	UCEC	ICGC	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation altering degron motif	0.7076
p.S2241N	TCGA-AP-A056	UCEC	TCGA	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation blocking phosphorylation signal	0.5278
p.S2241N	DO43971	UCEC	ICGC	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation blocking phosphorylation signal	0.5278
p.I1765V	TCGA-AP-A1DK	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.0556
p.K701T	TCGA-AX-A0J0	UCEC	TCGA	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7306
p.K701T	DO41133	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7306
p.S2339F	TCGA-B5-A11E	UCEC	TCGA	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.7982
p.S2339F	DO41644	UCEC	ICGC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.7982
p.K1963R	TCGA-B5-A3FA	UCEC	TCGA	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.0556
p.K1963R	DO52402	UCEC	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.0556
p.E1739G	TCGA-BR-8363	STAD	TCGA	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation altering degron motif	0.7199
p.N727S	TCGA-CQ-6219	HNSC	TCGA	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.2778
p.N727S	DO15054	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.2778
p.S691Y	TCGA-D3-A2JG	SKCM	TCGA	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.S691Y	DO47613	SKCM	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.Y1742F	TCGA-EB-A5UM	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation altering degron motif	0.7528
p.F1743L	TCGA-EB-A5UM	SKCM	TCGA	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation altering degron motif	0.6981
p.P2376L	TCGA-EE-A2A1	SKCM	TCGA	MQVHQD	LIG_APCC_ABBA_1	2373:2378	Mutation altering degron motif	0.7582
p.P2376L	DO38045	SKCM	ICGC	MQVHQD	LIG_APCC_ABBA_1	2373:2378	Mutation altering degron motif	0.7582
p.S2393L	TCGA-EJ-7331	PRAD	TCGA	AQSSS	DEG_SPOP_SBC_1	2384:2388	Mutation rewiring degron network	0.1944
p.S2393L	DO36301	PRAD	ICGC	AQSSS	DEG_SPOP_SBC_1	2384:2388	Mutation rewiring degron network	0.1944
p.R723H	TCGA-F5-6814	READ	TCGA	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.R723H	DO36556	READ	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.E2499K	TCGA-FD-A5BZ	BLCA	TCGA	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.2778
p.E2499K	DO44052	BLCA	ICGC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.2778
p.P2257S	TCGA-FU-A23L	CESC	TCGA	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.25
p.P2257S	DO6278	CESC	ICGC	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.25
p.P1759S	TCGA-FW-A3R5	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.2222
p.P1759L	TCGA-FW-A3R5	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.2222
p.H2484Y	TCGA-GC-A3RB	BLCA	TCGA	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.0833
p.H2484Y	DO530	BLCA	ICGC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.0833
p.R2342H	TCGA-HZ-7289	PAAD	TCGA	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8244
p.R2342H	DO32793	PAAD	ICGC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8244
p.M2247I	TCGA-VQ-A8P2	STAD	TCGA	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.25
p.M2247I	DO51761	STAD	ICGC	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.25
p.S702F	DO461	BLCA	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7982
p.S702F	DO42336	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7982
p.H1985D	DO875	BOCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.1944
p.E722K	DO217844	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1389
p.R735T	DO217844	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.3056
p.E734Q	DO224768	BRCA	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation altering degron motif	0.6744
p.N1981H	DO224977	BRCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.3056
p.V2063M	DO222454	BTCA	ICGC	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7208
p.I85N	DO8192	COAD	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation altering degron motif	0.728
p.R2352C	DO8898	COAD	ICGC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation rewiring degron network	0.0556
p.R2352C	DO8898	COAD	ICGC	ASTTT	DEG_SPOP_SBC_1	2347:2351	Mutation rewiring degron network	0.3056
p.Q744E	DO9924	COAD	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.0556
p.D84Y	DO234201	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation altering degron motif	0.7325
p.R2058C	DO234336	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8301
p.P740H	DO14766	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.P730H	DO14190	HNSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation altering degron motif	0.6583
p.V724F	DO228952	LICA	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1944
p.S721I	DO229015	LICA	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1111
p.L80F	DO229038	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation rewiring degron network	0.2222
p.N1981K	DO229038	LICA	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.3056
p.V2004L	DO229041	LICA	ICGC	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation altering degron motif	0.6765
p.S2047I	DO229041	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation rewiring degron network	0.1111
p.R697L	DO229045	LICA	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.R76G	DO50957	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation substituting flanking lysine	0.2222
p.F1750C	DO23174	LINC	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation rewiring degron network	0.1389
p.F1750C	DO23174	LINC	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.3056
p.G1751D	DO23362	LINC	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.7198
p.R76H	DO218944	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation substituting flanking lysine	0.2222
p.E95D	DO25444	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation rewiring degron network	0.1389
p.W1754C	DO24028	LUAD	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.7
p.C691Y	DO24780	LUAD	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.C691Y	ACH-000995	Leukemia	CCLE	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.C691Y	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1389
p.R1747T	DO231127	LUSC	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation rewiring degron network	0.2222
p.R1747T	DO231127	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.2222
p.Q744H	DO26596	LUSC	ICGC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.0556
p.E82Q	DO45532	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation rewiring degron network	0.2778
p.P1748L	DO222721	MELA	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation substituting flanking lysine	0.3056
p.P1748L	DO222721	MELA	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation substituting flanking lysine	0.3611
p.R74Q	DO222843	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation rewiring degron network	0.0556
p.I85T	DO51474	PACA	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation altering degron motif	0.7078
p.Q1996H	DO232761	PBCA	ICGC	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation blocking ubiquitination signal	0.7222
p.F1730L	DO47282	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation substituting flanking lysine	0.1944
p.Y1729F	DO47282	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation rewiring degron network	0.0556
p.P1746L	DO37406	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation rewiring degron network	0.25
p.P1746L	DO37406	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1944
p.P1746S	DO37406	SKCM	ICGC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation rewiring degron network	0.25
p.P1746S	DO37406	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation rewiring degron network	0.1944
p.N1983S	DO229264	THCA	ICGC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.25
p.I1752V	DO42033	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation altering degron motif	0.7076
p.R76S	DO41127	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation substituting flanking lysine	0.2222
p.R2058H	SIDM00193	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8244
p.R2058H	SNU-81	large intestine	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8244
p.A2495G	SIDM00835	Colorectal Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation altering degron motif	0.754
p.A2495G	ACH-000489	Colon/Colorectal Cancer	CCLE	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation altering degron motif	0.754
p.A2495G	SW1116	large intestine	COSMIC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation altering degron motif	0.754
p.V1976L	SIDM00683	Prostate Carcinoma	GDSC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation altering degron motif	0.6765
p.V1976L	LNCaP-Clone-FGC	prostate	COSMIC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation altering degron motif	0.6765
p.R2342C	SIDM00534	Colorectal Carcinoma	GDSC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R2342C	ACH-000986	Colon/Colorectal Cancer	CCLE	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R2342C	HT-115	large intestine	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R723C	SIDM00490	Glioma	GDSC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.R723C	Becker	central nervous system	COSMIC	DPENGE	DEG_Kelch_Keap1_1	729:734	Mutation rewiring degron network	0.1667
p.R1733Q	SIDM01609	Endometrial Carcinoma	GDSC	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation substituting flanking lysine	0.2778
p.R1733Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	VVSST	DEG_SPOP_SBC_1	1739:1743	Mutation substituting flanking lysine	0.2778
p.T1990I	SIDM01608	Endometrial Carcinoma	GDSC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.0556
p.T1990I	SIDM01608	Endometrial Carcinoma	GDSC	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation rewiring degron network	0.1111
p.T1990I	ACH-000990	Endometrial/Uterine Cancer	CCLE	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.0556
p.T1990I	ACH-000990	Endometrial/Uterine Cancer	CCLE	PETPKQT	DEG_SCF_FBW7_1	1998:2004	Mutation rewiring degron network	0.1111
p.T1762S	SIDM00158	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation blocking phosphorylation signal	0.5833
p.T1762S	ACH-000623	Brain Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	1751:1755	Mutation blocking phosphorylation signal	0.5833
p.K2050M	ACH-000879	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation substituting flanking lysine	0.3056
p.K2050M	MFE-296	endometrium	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation substituting flanking lysine	0.3056
p.P2371L	ACH-000976	Bile Duct Cancer	CCLE	MQVHQD	LIG_APCC_ABBA_1	2373:2378	Mutation rewiring degron network	0.2778
p.S77C	DoTc2-4510	cervix	COSMIC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation rewiring degron network	0.1389
p.R710C	Becker	central nervous system	COSMIC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.1111
p.M2502V	EN	endometrium	COSMIC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.1944
p.P2346L	Sarc9371	bone	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation blocking phosphorylation signal	0.6667
p.P2346L	Sarc9371	bone	COSMIC	ASTTT	DEG_SPOP_SBC_1	2347:2351	Mutation blocking phosphorylation signal	0.75
p.P86L	NCI-H1651	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation altering degron motif	0.7582
p.P2333L	Sarc9371	bone	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation rewiring degron network	0.25
p.T2058S	SW1990	pancreas	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.7116
p.V1963L	LNCaP-Clone-FGC	prostate	COSMIC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.0556
p.A2326V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation rewiring degron network	0.0556
p.R1985K	JVM-3	haematopoietic and lymphoid tissue	COSMIC	VPETPKET	DEG_SCF_FBW7_1	1973:1980	Mutation rewiring degron network	0.1944
p.K2501T	NCI-H1688	lung	COSMIC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation rewiring degron network	0.2222
p.R2329C	HT-115	large intestine	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation rewiring degron network	0.1389
p.S2249L	HOP-62	lung	COSMIC	ATSTS	DEG_SPOP_SBC_1	2250:2254	Mutation rewiring degron network	0.3056
p.R2045H	SNU-81	large intestine	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation rewiring degron network	0.0556
p.A2055T	NCI-H1155	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BPTF

UniProt ID: Q12830

Entrez ID: 2186

Protein name: Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BPTF in