DegronMD - Q12830(BPTF)

FUNCTION: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535)... View more >>

GO - Biological processes (BP): anterior/posterior pattern specification [GO:0009952]; brain development [GO:0007420]; chromatin remodeling [GO:0006338]; embryonic placenta development [GO:0001892]; endoderm development [GO:0007492]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleosome mobilization [G... View more >>

GO - Molecular function (MF): metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]

GO - Cellular component (CC): ATPase complex [GO:1904949]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NURF complex [GO:0016589]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2058C	DO234336	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8301
p.R2342C	SIDM00534	Colorectal Carcinoma	GDSC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R2342C	ACH-000986	Colon/Colorectal Cancer	CCLE	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R2342C	HT-115	large intestine	COSMIC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8301
p.R2342H	TCGA-HZ-7289	PAAD	TCGA	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8244
p.R2342H	DO32793	PAAD	ICGC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.8244
p.R2058H	SIDM00193	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8244
p.R2058H	SNU-81	large intestine	COSMIC	ATSTT	DEG_SPOP_SBC_1	2055:2059	Mutation altering degron motif	0.8244
p.S2339F	TCGA-B5-A11E	UCEC	TCGA	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.7982
p.S2339F	DO41644	UCEC	ICGC	LFTPLAT	DEG_SCF_FBW7_1	2336:2342	Mutation altering degron motif	0.7982
p.S702F	DO461	BLCA	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7982
p.S702F	DO42336	UCEC	ICGC	ATTTS	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7982
p.R2065T	TCGA-AC-A23H	BRCA	TCGA	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	TCGA-HU-A4GU	STAD	TCGA	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	DO2401	BRCA	ICGC	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.R2065T	DO47849	STAD	ICGC	PTSST	DEG_SPOP_SBC_1	2061:2065	Mutation altering degron motif	0.7876
p.P2376L	TCGA-EE-A2A1	SKCM	TCGA	MQVHQD	LIG_APCC_ABBA_1	2373:2378	Mutation altering degron motif	0.7582
p.P2376L	DO38045	SKCM	ICGC	MQVHQD	LIG_APCC_ABBA_1	2373:2378	Mutation altering degron motif	0.7582
p.P86L	NCI-H1651	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	84:88	Mutation altering degron motif	0.7582
p.A2495G	SIDM00835	Colorectal Carcinoma	GDSC	VQTTT	DEG_SPOP_SBC_1	2493:2497	Mutation altering degron motif	0.754

Showing 1 to 20 of 142 entries

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No resistance data available for this Degron.

Kaplan plot for BPTF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BPTF

UniProt ID: Q12830

Entrez ID: 2186

Protein name: Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for BPTF in