DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: LIG_APCC_ABBA_1

Location: 2373:2378

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8821

ASA_SCORE: 111.3

COIL: 0.871

CONS_SCORE: 0.3205

DSS_SCORE: 0.7825

HELIX: 0.0758

FCONS_SCORE: 1.0218

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2376L	TCGA-EE-A2A1	SKCM	TCGA	MQVHQD	LIG_APCC_ABBA_1	0.7582
p.P2376L	DO38045	SKCM	ICGC	MQVHQD	LIG_APCC_ABBA_1	0.7582
p.P2371L	ACH-000976	Bile Duct Cancer	CCLE	MQVHQD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12830	Nucleosome-remodeling factor subunit BPTF	LIG_APCC_ABBA_1	2373:2378	MQVHQD	APC,CDC20,FZR1	0.8821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons