DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SPOP_SBC_1

Location: 1751:1755

E3 ligase: SPOP

DEGRON score: 0.9422

ASA_SCORE: 95.7

COIL: 0.7256

CONS_SCORE: 0.3426

DSS_SCORE: 0.3608

HELIX: 0.0134

FCONS_SCORE: 1.0637

RIG_SCORE: 0.8034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1765V	TCGA-AP-A1DK	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.0556
p.P1759S	TCGA-FW-A3R5	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.2222
p.P1759L	TCGA-FW-A3R5	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.2222
p.F1750C	DO23174	LINC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.G1751D	DO23362	LINC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7198
p.W1754C	DO24028	LUAD	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7
p.R1747T	DO231127	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.P1748L	DO222721	MELA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.3611
p.P1746L	DO37406	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P1746S	DO37406	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.I1752V	DO42033	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7076
p.T1762S	SIDM00158	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.5833
p.T1762S	ACH-000623	Brain Cancer	CCLE	VTTTT	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons