DegronMD

Uniprot ID: Q12955

Source protein: Ankyrin-3

Source gene: ANK3

Class: DEG_SPOP_SBC_1

Location: 3959:3963

E3 ligase: SPOP

DEGRON score: 0.9114

ASA_SCORE: 91.66

COIL: 0.8822

CONS_SCORE: 0.2858

DSS_SCORE: 0.3456

HELIX: 0.0214

FCONS_SCORE: 1.0171

RIG_SCORE: 0.7854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3951A	DO229363	BTCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.V3959I	DO232224	PBCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7076
p.C3958R	SIDM00845	Burkitt's Lymphoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.C3958R	SIDM00461	Acute Myeloid Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	0.3056
p.L3950W	SIDM01588	Endometrial Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons