DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 763:767

E3 ligase: SPOP

DEGRON score: 0.7448

ASA_SCORE: 92.26

COIL: 0.8794

CONS_SCORE: 0.4534

DSS_SCORE: 0.4927

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.7931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G753C	TCGA-34-8455	LUSC	TCGA	VTTTT	DEG_SPOP_SBC_1	0.1667
p.G753C	DO50095	LUSC	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.W765L	TCGA-D3-A1Q3	SKCM	TCGA	VTTTT	DEG_SPOP_SBC_1	0.7015
p.W765L	DO47509	SKCM	ICGC	VTTTT	DEG_SPOP_SBC_1	0.7015
p.A755T	DO224639	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229010	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229013	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229016	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229003	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229005	COCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.A755T	DO229250	THCA	ICGC	VTTTT	DEG_SPOP_SBC_1	0.1111
p.T760A	SIDM00484	Thyroid Gland Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T760A	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T760A	SIDM00660	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T760A	SIDM01664	Prostate Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T760A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.T760A	SIDM01451	Pancreatic Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.P758H	SIDM00672	Hepatocellular Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P758H	SIDM00393	Gastric Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.P758H	SIDM00118	Colorectal Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1944
p.S771L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VTTTT	DEG_SPOP_SBC_1	0.2222
p.K756E	SIDM00591	Oral Cavity Carcinoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.25
p.K753Q	SIDM01336	Glioblastoma	GDSC	VTTTT	DEG_SPOP_SBC_1	0.1667
p.A755V	ACH-000939	Sarcoma	CCLE	VTTTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	625:629	VTTTT	SPOP	0.9294	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	388:392	VTTTT	SPOP	0.8483	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	763:767	VTTTT	SPOP	0.7448	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1516:1520	VTTTT	SPOP	0.7066	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1893:1897	VTTTT	SPOP	0.6112	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	1751:1755	VTTTT	SPOP	0.9422	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	3959:3963	VTTTT	SPOP	0.9114	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6984:6988	VTTTT	SPOP	0.9363	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7102:7106	VTTTT	SPOP	0.7934	More...
Q8TCZ2	CD99 antigen-like protein 2	DEG_SPOP_SBC_1	98:102	VTTTT	SPOP	0.9976	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	222:226	VTTTT	SPOP	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons