DegronMD - Q9P265(DIP2B)

FUNCTION: Negatively regulates axonal outgrowth and is essential for normal synaptic transmission. Not required for regulation of axon polarity. Promotes acetylation of alpha-tubulin. {ECO:0000250|UniProtKB:Q3UH60}.

GO - Biological processes (BP): negative regulation of axon extension [GO:0030517]; positive regulation of peptidyl-lysine acetylation [GO:2000758]

GO - Molecular function (MF): alpha-tubulin binding [GO:0043014]

GO - Cellular component (CC): axon [GO:0030424]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perikaryon [GO:0043204]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T144A	TCGA-DD-AADD	LIHC	TCGA	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.825
p.T144A	DO52231	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.825
p.P142L	SIDM00333	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.P142L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.P142L	MFE-319	endometrium	COSMIC	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation altering degron motif	0.7582
p.T226I	DO225346	BRCA	ICGC	VTTTT	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.7078
p.S153F	TCGA-LN-A5U6	ESCA	TCGA	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.5833
p.S228F	DO222536	MELA	ICGC	VTTTT	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.2778
p.E149K	TCGA-JW-A5VL	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.E149K	DO49976	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.D95Y	TCGA-38-4625	LUAD	TCGA	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.D95Y	DO23952	LUAD	ICGC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.A109P	SIDM00516	Melanoma	GDSC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.A109P	SIDM01879	Non-Cancerous	GDSC	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.A109P	ACH-002361	Non-Cancerous	CCLE	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.D95V	ACH-000973	Bladder Cancer	CCLE	RSDIHTE	LIG_APCC_ABBAyCdc20_2	99:105	Mutation rewiring degron network	0.2222
p.S217C	TCGA-DF-A2KR	UCEC	TCGA	VTTTT	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1944
p.S217C	DO223284	UCEC	ICGC	VTTTT	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.1944
p.E151D	SIDM01609	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.E151D	ACH-000972	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 33 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIP2B

UniProt ID: Q9P265

Entrez ID: 57609

Protein name: Disco-interacting protein 2 homolog B (DIP2 homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIP2B in