DegronMD

Uniprot ID: Q9P265

Source protein: Disco-interacting protein 2 homolog B

Source gene: DIP2B

Class: DEG_SPOP_SBC_1

Location: 142:146

E3 ligase: SPOP

DEGRON score: 0.9674

ASA_SCORE: 87.88

COIL: 0.9454

CONS_SCORE: 0.1392

DSS_SCORE: 0.7053

HELIX: 0.0402

FCONS_SCORE: 0.8798

RIG_SCORE: 0.609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T144A	TCGA-DD-AADD	LIHC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.825
p.T144A	DO52231	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.825
p.E149K	TCGA-JW-A5VL	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.25
p.E149K	DO49976	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.25
p.G152C	TCGA-L9-A7SV	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1667
p.G152C	DO49875	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.S153F	TCGA-LN-A5U6	ESCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.5833
p.G152V	DO228976	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.P142L	SIDM00333	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.7582
p.P142L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.7582
p.P142L	MFE-319	endometrium	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.7582
p.E151D	SIDM01609	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.E151D	ACH-000972	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons