DegronMD

Uniprot ID: Q8N485

Source protein: Protein limb expression 1 homolog

Source gene: LIX1

Class: DEG_SPOP_SBC_1

Location: 263:267

E3 ligase: SPOP

DEGRON score: 0.8481

ASA_SCORE: 79.1

COIL: 0.9268

CONS_SCORE: 0.5657

DSS_SCORE: 0.4208

HELIX: 0.0518

FCONS_SCORE: 0.8004

RIG_SCORE: 0.6517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D271N	TCGA-FS-A4FD	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.2222
p.D271N	DO37699	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.P268T	DO222783	BTCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.T276A	DO222880	MELA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.P263T	SIDM00120	Prostate Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.7031
p.P263T	ACH-000979	Prostate Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.7031
p.P263T	DU-145	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons