DegronMD - Q6PCT2(FBXL19)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S326A	TCGA-06-2566	GBM	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056
p.R578C	TCGA-24-1423	OV	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.25
p.R319L	TCGA-64-5778	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2778
p.A292T	TCGA-AB-2807	LAML	TCGA	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6028
p.A580G	TCGA-AC-A6IW	BRCA	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1944
p.R309C	TCGA-AP-A1DV	UCEC	TCGA	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.D335N	TCGA-AX-A2HC	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.G7R	TCGA-B6-A0RL	BRCA	TCGA	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.0833
p.G7R	DO3644	BRCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.0833
p.W282R	TCGA-BG-A222	UCEC	TCGA	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.L317M	TCGA-CN-6010	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.S325Y	TCGA-D3-A2JP	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.712
p.S332F	TCGA-D6-6516	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1389
p.G573W	TCGA-ER-A19P	SKCM	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation altering degron motif	0.6714
p.G581D	TCGA-F4-6809	COAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1667
p.R578H	TCGA-G4-6309	COAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.25
p.R309H	TCGA-MN-A4N5	LUAD	TCGA	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.R309H	SIDM01693	B-Lymphoblastic Leukemia	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.R309H	ACH-000032	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.S328L	TCGA-S5-A6DX	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.25
p.P287L	TCGA-WS-AB45	COAD	TCGA	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.2222
p.R568C	TCGA-XK-AAIW	PRAD	TCGA	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation altering degron motif	0.8301
p.S308L	DO51903	BLCA	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.1111
p.S317L	DO219078	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.S317L	DO51259	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.S320L	DO457	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056
p.S320L	DO222875	MELA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.3056
p.C25S	DO225195	BRCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.25
p.C25S	DO225195	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.A560G	DO50028	BRCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation blocking phosphorylation signal	0.5833
p.E329K	DO3940	BRCA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.E329K	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2222
p.R331Q	DO222574	BTCA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.R23Q	DO44362	CESC	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7329
p.R335W	DO10550	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0556
p.G561D	DO10164	COAD	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation blocking ubiquitination signal	0.6111
p.R558H	DO7810	COAD	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.0833
p.R558H	DO233168	GACA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.0833
p.D583E	DO52483	COCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1111
p.E10K	DO229010	COCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1667
p.E10K	DO229010	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.E10K	DO229013	COCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1667
p.E10K	DO229013	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.0556
p.R20H	DO223130	ESCA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.8244
p.R20H	DO223130	ESCA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.8244
p.A581T	DO233644	GACA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1667
p.A581T	DO28062	OV	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1667
p.A581T	DO223286	UCEC	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.1667
p.S306A	DO11507	GBM	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation substituting flanking lysine	0.2778
p.L297M	DO14766	HNSC	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.711
p.S312F	DO15623	HNSC	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.0833
p.R13C	DO20780	KIRP	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.25
p.R13C	DO20780	KIRP	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.R18L	DO228948	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.8428
p.A576S	DO228974	LICA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.3056
p.G561V	DO229028	LICA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation blocking ubiquitination signal	0.6111
p.R15L	DO229022	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.3056
p.R15L	DO229022	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1944
p.C25F	DO229027	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.25
p.C25F	DO229027	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.3056
p.D315Y	DO229008	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.G9R	DO50970	LICA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1389
p.R13H	DO23368	LINC	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.25
p.R13H	DO23368	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.R299L	DO25837	LUAD	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.8428
p.R289H	DO45332	LUAD	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.2778
p.R570H	DO52674	MALY	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation altering degron motif	0.7133
p.A24T	DO228855	MALY	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7139
p.P6S	DO222595	MELA	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.0556
p.R558C	DO30080	OV	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.0833
p.R558C	DO229257	THCA	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.0833
p.L321V	DO29920	OV	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6765
p.R27L	DO50268	PAAD	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1944
p.R27L	DO50268	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.G31E	DO219387	PRAD	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.0833
p.G31E	DO219387	PRAD	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1389
p.R331W	DO37519	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.R331W	DO37408	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.S305Y	DO47407	SKCM	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.1944
p.R289C	DO43186	UCEC	ICGC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.2778
p.D315N	DO41572	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1667
p.T28S	DO43755	UCEC	ICGC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1667
p.T28S	DO43755	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.2222
p.A576T	DO42713	UCEC	ICGC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation rewiring degron network	0.3056
p.P300L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.P300L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.P300L	ACH-000917	Esophageal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.P300L	ACH-000920	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.P300L	TE-4	oesophagus	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.P300L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6471
p.S324T	SIDM00969	Ovarian Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6005
p.S324T	DOV13	ovary	COSMIC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation altering degron motif	0.6005
p.E308Q	SIDM00938	Breast Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.1111
p.E308Q	ACH-000902	Breast Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.1111
p.E308Q	CAL-148	breast	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.1111
p.P300S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6752
p.P300S	ACH-000809	Esophageal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6752
p.P300S	KYSE-410	oesophagus	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6752
p.G294D	SIDM00299	Other Sarcomas	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6087
p.G294D	ACH-002271	Sarcoma	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6087
p.G294D	MFH-ino	soft tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6087
p.G27V	SIDM01622	Breast Carcinoma	GDSC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1944
p.G27V	SIDM01622	Breast Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.G27V	ACH-000721	Breast Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.1944
p.G27V	ACH-000721	Breast Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.25
p.V297L	SIDM01473	Plasma Cell Myeloma	GDSC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6765
p.D333N	SIDM01619	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1111
p.S22L	ACH-000441	Skin Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.7667
p.S22L	ACH-000441	Skin Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.7667
p.A296T	ACH-000967	Colon/Colorectal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6028
p.A296T	ACH-001199	Colon/Colorectal Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6028
p.A296T	ACH-001738	Leukemia	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6028
p.A296T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation altering degron motif	0.6028
p.D21N	ACH-000984	Endometrial/Uterine Cancer	CCLE	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation altering degron motif	0.6932
p.D21N	ACH-000984	Endometrial/Uterine Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation altering degron motif	0.6932
p.T310M	ACH-002250	Head and Neck Cancer	CCLE	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0556
p.T310M	JHU-022	upper aerodigestive tract	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0556
p.G333V	NCI-H345	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1111
p.G333W	NCI-H345	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.1111
p.S304T	DOV13	ovary	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.2222
p.R282H	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.0833
p.R574H	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	SRGRLQGVA	DEG_APCC_DBOX_1	567:575	Mutation altering degron motif	0.8244
p.R327G	MDA-MB-415	breast	COSMIC	PDTSS	DEG_SPOP_SBC_1	321:325	Mutation rewiring degron network	0.2778
p.E288Q	CAL-148	breast	COSMIC	SAEGPAVPSP	DEG_COP1_1	291:300	Mutation rewiring degron network	0.25
p.S12T	DOV13	ovary	COSMIC	LLTPPMS	DEG_SCF_FBW7_1	16:22	Mutation rewiring degron network	0.2222
p.S12T	DOV13	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	20:24	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXL19

UniProt ID: Q6PCT2

Entrez ID: 54620

Protein name: F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXL19 in