DegronMD

Uniprot ID: Q6PCT2

Source protein: F-box/LRR-repeat protein 19

Source gene: FBXL19

Class: DEG_SPOP_SBC_1

Location: 20:24

E3 ligase: SPOP

DEGRON score: 0.8896

ASA_SCORE: 89.96

COIL: 0.9564

CONS_SCORE: 0.4175

DSS_SCORE: 0.7235

HELIX: 0.0322

FCONS_SCORE: 0.9866

RIG_SCORE: 0.5841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C25S	DO225195	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.3056
p.R23Q	DO44362	CESC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7329
p.E10K	DO229010	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.E10K	DO229013	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.0556
p.R20H	DO223130	ESCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.8244
p.R13C	DO20780	KIRP	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1389
p.R15L	DO229022	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1944
p.C25F	DO229027	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.3056
p.R13H	DO23368	LINC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1389
p.A24T	DO228855	MALY	ICGC	PMSSS	DEG_SPOP_SBC_1	0.7139
p.R27L	DO50268	PAAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.25
p.G31E	DO219387	PRAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1389
p.T28S	DO43755	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2222
p.G27V	SIDM01622	Breast Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.25
p.G27V	ACH-000721	Breast Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.25
p.S22L	ACH-000441	Skin Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.7667
p.D21N	ACH-000984	Endometrial/Uterine Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.6932
p.S12T	DOV13	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons