DegronMD - P01266(TG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L2745F	TCGA-29-1694	OV	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.1667
p.S2446Y	TCGA-60-2706	LUSC	TCGA	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.712
p.S2757T	TCGA-86-8672	LUAD	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.6005
p.C2442F	TCGA-AA-A01S	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.3056
p.G2748A	TCGA-BA-A6DA	HNSC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.25
p.S2763T	TCGA-CC-A9FW	LIHC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.2222
p.M2444T	TCGA-CV-7245	HNSC	TCGA	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6312
p.S2757R	TCGA-D1-A15X	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.6316
p.Y2766C	TCGA-D1-A1NY	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.1389
p.E2743D	TCGA-D1-A2G0	UCEC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.1111
p.E2742K	TCGA-D3-A8GL	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.0833
p.E2753K	TCGA-EK-A3GK	CESC	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.591
p.R2455C	TCGA-FR-A3YO	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.1111
p.R2455C	SIDM00011	Melanoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.1111
p.A2747T	TCGA-GN-A26C	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.2222
p.E2741K	TCGA-H4-A2HQ	BLCA	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.0556
p.T2746M	TCGA-RP-A690	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.1944
p.E2744K	TCGA-W3-AA21	SKCM	TCGA	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.1389
p.E2741G	SIDM00722	Mesothelioma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.0556
p.E2741G	NCI-H2452	pleura	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation rewiring degron network	0.0556
p.L2758F	SIDM00190	Melanoma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.6981
p.L2758F	ACH-002097	Skin Cancer	CCLE	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.6981
p.L2758F	CP66-MEL	skin	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.6981
p.M2444I	SIDM00282	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.M2444I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.M2444I	ACH-000998	Colon/Colorectal Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.M2444I	ACH-001127	Leukemia	CCLE	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.M2444I	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.M2444I	CW-2	large intestine	COSMIC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.6507
p.R2455H	SIDM00574	Glioblastoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.1111
p.R2455H	SIDM00579	Neuroblastoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.1111
p.R2455H	SIDM01782	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.1111
p.V2440I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.25
p.V2440I	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation rewiring degron network	0.25
p.L2756R	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.7316
p.L2756R	ACH-002221	Lymphoma	CCLE	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.7316
p.L2756R	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LREDLLSLQ	DEG_APCC_DBOX_1	2751:2759	Mutation altering degron motif	0.7316
p.K2457R	SIDM00554	Ovarian Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation substituting flanking lysine	0.1667
p.K2457R	KURAMOCHI	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation substituting flanking lysine	0.1667
p.S2447R	SIDM00975	Melanoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.7427
p.S2447R	ACH-002206	Skin Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.7427
p.S2447R	WM278	skin	COSMIC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.7427
p.S2446F	SIDM01782	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	2443:2447	Mutation altering degron motif	0.7982

Kaplan plot for TG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TG

UniProt ID: P01266

Entrez ID: 7038

Protein name: Thyroglobulin (Tg)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TG in