DegronMD

Uniprot ID: P01266

Source protein: Thyroglobulin

Source gene: TG

Class: DEG_SPOP_SBC_1

Location: 2443:2447

E3 ligase: SPOP

DEGRON score: 0.5138

ASA_SCORE: 68.12

COIL: 0.8504

CONS_SCORE: 0.3646

DSS_SCORE: 0.1945

HELIX: 0.1396

FCONS_SCORE: 0.7329

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2446Y	TCGA-60-2706	LUSC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.712
p.C2442F	TCGA-AA-A01S	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.3056
p.M2444T	TCGA-CV-7245	HNSC	TCGA	PMSSS	DEG_SPOP_SBC_1	0.6312
p.R2455C	TCGA-FR-A3YO	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1111
p.R2455C	SIDM00011	Melanoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.M2444I	SIDM00282	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6507
p.M2444I	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PMSSS	DEG_SPOP_SBC_1	0.6507
p.M2444I	ACH-000998	Colon/Colorectal Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.6507
p.M2444I	ACH-001127	Leukemia	CCLE	PMSSS	DEG_SPOP_SBC_1	0.6507
p.M2444I	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.6507
p.M2444I	CW-2	large_intestine	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.6507
p.R2455H	SIDM00574	Glioblastoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.R2455H	SIDM00579	Neuroblastoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.R2455H	SIDM01782	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.V2440I	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.25
p.V2440I	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.25
p.K2457R	SIDM00554	Ovarian Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.K2457R	KURAMOCHI	ovary	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.S2447R	SIDM00975	Melanoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.7427
p.S2447R	ACH-002206	Skin Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	0.7427
p.S2447R	WM278	skin	COSMIC	PMSSS	DEG_SPOP_SBC_1	0.7427
p.S2446F	SIDM01782	Oral Cavity Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons