DegronMD

Uniprot ID: O15062

Source protein: Zinc finger and BTB domain-containing protein 5

Source gene: ZBTB5

Class: DEG_SPOP_SBC_1

Location: 170:174

E3 ligase: SPOP

DEGRON score: 0.8158

ASA_SCORE: 82.54

COIL: 0.8458

CONS_SCORE: 0.5996

DSS_SCORE: 0.8036

HELIX: 0.1352

FCONS_SCORE: 0.9867

RIG_SCORE: 0.5819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R182C	TCGA-AA-3864	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1111
p.R182C	DO8490	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1111
p.D180H	TCGA-BH-A0E7	BRCA	TCGA	PMSSS	DEG_SPOP_SBC_1	0.1667
p.D180H	DO4998	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.1667
p.R176H	TCGA-VQ-A8P2	STAD	TCGA	PMSSS	DEG_SPOP_SBC_1	0.2778
p.R176H	DO228542	GACA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.R176H	DO51761	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.R176C	DO227745	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.2778
p.M171I	DO228948	LICA	ICGC	PMSSS	DEG_SPOP_SBC_1	0.6507
p.A169T	DO30340	OV	ICGC	PMSSS	DEG_SPOP_SBC_1	0.3056
p.M175T	SIDM01650	Non-Cancerous	GDSC	PMSSS	DEG_SPOP_SBC_1	0.3056
p.S174C	ACH-001184	Sarcoma	CCLE	PMSSS	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	170:174	PMSSS	SPOP	0.8158	More...
P01266	Thyroglobulin	DEG_SPOP_SBC_1	2443:2447	PMSSS	SPOP	0.5138	More...
P39880	Homeobox protein cut-like 1	DEG_SPOP_SBC_1	1060:1064	PMSSS	SPOP	0.9994	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	285:289	PMSSS	SPOP	0.9583	More...
Q6AWC2	Protein WWC2	DEG_SPOP_SBC_1	569:573	PMSSS	SPOP	0.827	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	20:24	PMSSS	SPOP	0.8896	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	610:614	PMSSS	SPOP	0.8719	More...
Q9H0N0	Ras-related protein Rab-6C	DEG_SPOP_SBC_1	211:215	PMSSS	SPOP	0.9712	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	180:184	PMSSS	SPOP	0.5585	More...
Q9ULL8	Protein Shroom4	DEG_SPOP_SBC_1	813:817	PMSSS	SPOP	0.7425	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1527:1531	PMSSS	SPOP	0.9987	More...
Q9NW07	Zinc finger protein 358	DEG_SPOP_SBC_1	87:91	PMSSS	SPOP	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons