DegronMD - Q9H4Z2(ZNF335)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P389S	TCGA-19-2621	GBM	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2778
p.G212V	TCGA-56-7823	LUSC	TCGA	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.E390D	TCGA-66-2756	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.3056
p.D198H	TCGA-69-7980	LUAD	TCGA	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.Q387H	TCGA-91-6836	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.H93Y	TCGA-AA-3524	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.H93Y	DO8011	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.25
p.A192V	TCGA-AA-3984	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.A192V	TCGA-AA-3984	COAD	TCGA	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.A192V	TCGA-BK-A6W3	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.A192V	TCGA-BK-A6W3	UCEC	TCGA	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.R1139W	TCGA-AP-A0LM	UCEC	TCGA	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.R1139W	SIDM00362	Burkitt's Lymphoma	GDSC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.R1139W	ACH-000321	Leukemia	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.R1139W	ACH-002293	Lymphoma	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.R1139W	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.D172G	TCGA-AX-A1C9	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.D172G	DO43098	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.E1156K	TCGA-B5-A11E	UCEC	TCGA	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.1111
p.A402V	TCGA-B5-A3FC	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.A402V	TCGA-BF-AAP1	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1389
p.E903K	TCGA-CN-4735	HNSC	TCGA	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.3056
p.P200H	TCGA-D9-A149	SKCM	TCGA	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7694
p.P383H	TCGA-EY-A215	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1111
p.S89L	TCGA-FI-A2D5	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7667
p.S89L	DO41331	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7667
p.S89L	SIDM01060	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7667
p.S89L	ACH-000882	Skin Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7667
p.S89L	IGR-1	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7667
p.S189N	TCGA-FR-A7U9	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.P904L	TCGA-FS-A1ZA	SKCM	TCGA	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.2778
p.L400M	TCGA-IB-7651	PAAD	TCGA	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.P61L	DO532	BLCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.2778
p.P61L	DO231036	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.2778
p.R65S	DO225056	BRCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.1667
p.E174K	DO44238	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1667
p.A2P	DO219619	BRCA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.P400L	DO229378	BTCA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.R98Q	DO6260	CESC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.R98Q	DO8224	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.R98Q	DO49657	LIHC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.D393N	DO10582	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.6932
p.C95Y	DO7855	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.R392W	DO230312	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.8634
p.R392W	DO229096	UTCA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.8634
p.P86H	DO48195	ESCA	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7694
p.G1157S	DO233156	GACA	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.0833
p.E906K	DO233259	GACA	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.2222
p.R98W	DO233840	GACA	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1111
p.D1149G	DO233865	GACA	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.3056
p.H390P	DO233916	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.3056
p.D61Y	DO233903	GACA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.2778
p.R385W	DO10975	GBM	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.R385W	DO41758	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.V86M	DO44433	HNSC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation altering degron motif	0.7208
p.D1149H	DO15631	HNSC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.3056
p.A17V	DO228916	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1389
p.H386Q	DO228952	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.T15K	DO229019	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.V62M	DO229039	LICA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.25
p.S100R	DO229006	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0556
p.A387S	DO52275	LIHC	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.E174D	DO23765	LUAD	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1667
p.R178W	DO45330	LUAD	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2778
p.R178W	DO232761	PBCA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2778
p.R385L	DO24780	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.D43H	DO23678	LUAD	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.0556
p.A887S	DO26015	LUAD	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.0833
p.G170S	DO230525	LUSC	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0556
p.V62L	DO230974	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.25
p.V62L	DO224632	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.25
p.G56R	DO231078	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation altering degron motif	0.7568
p.R200W	DO26446	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.8634
p.R200W	DO38006	SKCM	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.8634
p.R200W	DO51773	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.8634
p.E172K	DO45526	LUSC	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.G57V	DO223721	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation altering degron motif	0.6421
p.P192S	DO27421	LUSC	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.P192S	DO27421	LUSC	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.P192S	DO47833	STAD	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1111
p.P192S	DO47833	STAD	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.C51F	DO50705	ORCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.2778
p.R178Q	DO35442	PACA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2778
p.R181Q	DO232761	PBCA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation altering degron motif	0.7329
p.S188C	DO46877	RECA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2222
p.E1137Q	DO220176	SARC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2222
p.V99G	DO219881	SKCA	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.0833
p.P187S	DO218900	SKCA	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.R908L	DO37643	SKCM	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.1667
p.P400S	DO37410	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.P45H	DO37420	SKCM	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.1111
p.R902H	DO50288	SKCM	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation altering degron motif	0.8244
p.R902H	DO52419	UCEC	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation altering degron motif	0.8244
p.P61Q	DO47613	SKCM	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.2778
p.R902S	DO47849	STAD	ICGC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation altering degron motif	0.7427
p.D53H	DO229192	THCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation altering degron motif	0.7688
p.D43Y	DO229259	THCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	53:59	Mutation rewiring degron network	0.0556
p.K395N	DO39151	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.6918
p.A1143V	DO42033	UCEC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation altering degron motif	0.6936
p.R198W	DO42033	UCEC	ICGC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.K91R	DO42023	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.3056
p.P175H	DO43258	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.A80D	DO42472	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1667
p.P95S	SIDM01307	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.1944
p.Q910R	SIDM02021	Esophageal Carcinoma	GDSC	PGTPYSE	DEG_SCF_FBW7_2	896:902	Mutation rewiring degron network	0.1111
p.A197V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.A197V	ACH-000995	Leukemia	CCLE	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.S189C	SIDM00270	Head and Neck Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.S189C	ACH-002294	Head and Neck Cancer	CCLE	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.S189C	PCI-15A	upper aerodigestive tract	COSMIC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.N4T	SIDM00789	Colorectal Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.N4T	ACH-000997	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.N4T	ACH-001061	Colon/Colorectal Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2778
p.P14L	SIDM00418	Thyroid Gland Carcinoma	GDSC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.P14L	ACH-000716	Thyroid Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.P14L	TT2609-C02	thyroid	COSMIC	VESSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.2222
p.G94W	SIDM00489	Oral Cavity Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.G94W	ACH-002043	Head and Neck Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.G94W	Ca9-22	upper aerodigestive tract	COSMIC	PDSSS	DEG_SPOP_SBC_1	86:90	Mutation rewiring degron network	0.2222
p.R1139Q	SIDM00221	Melanoma	GDSC	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.R1139Q	ACH-002388	Skin Cancer	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	1141:1148	Mutation rewiring degron network	0.2778
p.P392S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.5641
p.P392S	ACH-000891	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.5641
p.I193T	SIDM01433	Kidney Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0833
p.I193T	SIDM01433	Kidney Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.I193T	SIDM01729	Endometrial Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0833
p.I193T	SIDM01729	Endometrial Carcinoma	GDSC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.G211S	CMK	haematopoietic and lymphoid tissue	COSMIC	PTSTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF335

UniProt ID: Q9H4Z2

Entrez ID: 63925

Protein name: Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF335 in