DegronMD

Uniprot ID: Q9H4Z2

Source protein: Zinc finger protein 335

Source gene: ZNF335

Class: DEG_SCF_FBW7_2

Location: 896:902

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 71.6143

COIL: 0.773

CONS_SCORE: 0.4942

DSS_SCORE: 0.7136

HELIX: 0.0371

FCONS_SCORE: 1.1164

RIG_SCORE: 0.6439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E903K	TCGA-CN-4735	HNSC	TCGA	PGTPYSE	DEG_SCF_FBW7_2	0.3056
p.P904L	TCGA-FS-A1ZA	SKCM	TCGA	PGTPYSE	DEG_SCF_FBW7_2	0.2778
p.E906K	DO233259	GACA	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.2222
p.A887S	DO26015	LUAD	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.0833
p.R908L	DO37643	SKCM	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.1667
p.R902H	DO50288	SKCM	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.8244
p.R902H	DO52419	UCEC	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.8244
p.R902S	DO47849	STAD	ICGC	PGTPYSE	DEG_SCF_FBW7_2	0.7427
p.Q910R	SIDM02021	Esophageal Carcinoma	GDSC	PGTPYSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Z2	Zinc finger protein 335	DEG_SCF_FBW7_2	896:902	PGTPYSE	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons