DegronMD

Uniprot ID: Q9H4Z2

Source protein: Zinc finger protein 335

Source gene: ZNF335

Class: DEG_SCF_TRCP1_1

Location: 53:59

E3 ligase: BTRC

DEGRON score: 0.9827

ASA_SCORE: 62.1429

COIL: 0.8274

CONS_SCORE: 0.4188

DSS_SCORE: 0.7954

HELIX: 0.0654

FCONS_SCORE: 1.1263

RIG_SCORE: 0.5599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P61L	DO532	BLCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.2778
p.P61L	DO231036	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.2778
p.R65S	DO225056	BRCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.1667
p.D61Y	DO233903	GACA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.2778
p.V62M	DO229039	LICA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.25
p.D43H	DO23678	LUAD	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.0556
p.V62L	DO230974	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.25
p.V62L	DO224632	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.25
p.G56R	DO231078	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.7568
p.G57V	DO223721	LUSC	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.6421
p.C51F	DO50705	ORCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.2778
p.P45H	DO37420	SKCM	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.1111
p.P61Q	DO47613	SKCM	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.2778
p.D53H	DO229192	THCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.7688
p.D43Y	DO229259	THCA	ICGC	DSGVGQS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Z2	Zinc finger protein 335	DEG_SCF_TRCP1_1	53:59	DSGVGQS	BTRC	0.9827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons