DegronMD

Uniprot ID: Q9H4Z2

Source protein: Zinc finger protein 335

Source gene: ZNF335

Class: DEG_SCF_FBW7_1

Location: 1141:1148

E3 ligase: FBXW7

DEGRON score: 0.9511

ASA_SCORE: 70.075

COIL: 0.7233

CONS_SCORE: 0.4494

DSS_SCORE: 0.6923

HELIX: 0.0941

FCONS_SCORE: 0.6539

RIG_SCORE: 0.7099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1139W	TCGA-AP-A0LM	UCEC	TCGA	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.R1139W	SIDM00362	Burkitt's Lymphoma	GDSC	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.R1139W	ACH-000321	Leukemia	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.R1139W	ACH-002293	Lymphoma	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.R1139W	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.E1156K	TCGA-B5-A11E	UCEC	TCGA	PTQTPTQT	DEG_SCF_FBW7_1	0.1111
p.G1157S	DO233156	GACA	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	0.0833
p.D1149G	DO233865	GACA	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	0.3056
p.D1149H	DO15631	HNSC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	0.3056
p.E1137Q	DO220176	SARC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	0.2222
p.A1143V	DO42033	UCEC	ICGC	PTQTPTQT	DEG_SCF_FBW7_1	0.6936
p.R1139Q	SIDM00221	Melanoma	GDSC	PTQTPTQT	DEG_SCF_FBW7_1	0.2778
p.R1139Q	ACH-002388	Skin Cancer	CCLE	PTQTPTQT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Z2	Zinc finger protein 335	DEG_SCF_FBW7_1	1141:1148	PTQTPTQT	FBXW7	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons