DegronMD

Uniprot ID: Q9H4Z2

Source protein: Zinc finger protein 335

Source gene: ZNF335

Class: DEG_SPOP_SBC_1

Location: 86:90

E3 ligase: SPOP

DEGRON score: 0.9916

ASA_SCORE: 73.16

COIL: 0.7258

CONS_SCORE: 0.4772

DSS_SCORE: 0.594

HELIX: 0.2436

FCONS_SCORE: 1.0634

RIG_SCORE: 0.5738

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P86H	DO48195	ESCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7694
p.S89L	TCGA-FI-A2D5	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	0.7667
p.S89L	DO41331	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7667
p.S89L	SIDM01060	Melanoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.7667
p.S89L	ACH-000882	Skin Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.7667
p.S89L	IGR-1	skin	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.7667
p.V86M	DO44433	HNSC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.7208
p.K91R	DO42023	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.3056
p.H93Y	TCGA-AA-3524	COAD	TCGA	PDSSS	DEG_SPOP_SBC_1	0.25
p.H93Y	DO8011	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.25
p.G94W	SIDM00489	Oral Cavity Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.2222
p.G94W	ACH-002043	Head and Neck Cancer	CCLE	PDSSS	DEG_SPOP_SBC_1	0.2222
p.G94W	Ca9-22	upper_aerodigestive_tract	COSMIC	PDSSS	DEG_SPOP_SBC_1	0.2222
p.C95Y	DO7855	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1944
p.P95S	SIDM01307	Colorectal Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	0.1944
p.A80D	DO42472	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1667
p.R98Q	DO6260	CESC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.R98Q	DO8224	COAD	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.R98Q	DO49657	LIHC	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.R98W	DO233840	GACA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.1111
p.V99G	DO219881	SKCA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0833
p.S100R	DO229006	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 22 of 22 entries

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Drug responses associated with ZNF335 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PDSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	DEG_SPOP_SBC_1	945:949	PDSSS	SPOP	0.9951	More...
Q15642	Cdc42-interacting protein 4	DEG_SPOP_SBC_1	498:502	PDSSS	SPOP	0.9962	More...
Q9NXG0	Centlein	DEG_SPOP_SBC_1	1396:1400	PDSSS	SPOP	0.9251	More...
Q8N441	Fibroblast growth factor receptor-like 1	DEG_SPOP_SBC_1	129:133	PDSSS	SPOP	0.8851	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	1863:1867	PDSSS	SPOP	0.902	More...
Q5H9T9	Fibrous sheath CABYR-binding protein	DEG_SPOP_SBC_1	170:174	PDSSS	SPOP	0.9796	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	260:264	PDSSS	SPOP	0.9877	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	310:314	PDSSS	SPOP	0.9763	More...
P31267	Homeobox protein Hox-A6	DEG_SPOP_SBC_1	113:117	PDSSS	SPOP	0.545	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	157:161	PDSSS	SPOP	0.9993	More...
Q9NWZ3	Interleukin-1 receptor-associated kinase 4	DEG_SPOP_SBC_1	148:152	PDSSS	SPOP	0.9855	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	515:519	PDSSS	SPOP	0.9977	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	302:306	PDSSS	SPOP	0.9992	More...
Q86VZ4	Low-density lipoprotein receptor-related protein 11	DEG_SPOP_SBC_1	417:421	PDSSS	SPOP	0.9592	More...
P23760	Paired box protein Pax-3	DEG_SPOP_SBC_1	348:352	PDSSS	SPOP	0.9277	More...
P56645	Period circadian protein homolog 3	DEG_SPOP_SBC_1	748:752	PDSSS	SPOP	0.8579	More...
Q9BWT3	Poly	DEG_SPOP_SBC_1	712:716	PDSSS	SPOP	0.9943	More...
Q7Z333	Probable helicase senataxin	DEG_SPOP_SBC_1	1485:1489	PDSSS	SPOP	0.8761	More...
Q93008	Probable ubiquitin carboxyl-terminal hydrolase FAF-X	DEG_SPOP_SBC_1	976:980	PDSSS	SPOP	0.9934	More...
O00507	Probable ubiquitin carboxyl-terminal hydrolase FAF-Y	DEG_SPOP_SBC_1	977:981	PDSSS	SPOP	0.9861	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	567:571	PDSSS	SPOP	0.9916	More...
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_SPOP_SBC_1	152:156	PDSSS	SPOP	0.7282	More...
Q14517	Protocadherin Fat 1	DEG_SPOP_SBC_1	1166:1170	PDSSS	SPOP	0.9878	More...
P13985	Putative HTLV-1-related endogenous sequence	DEG_SPOP_SBC_1	139:143	PDSSS	SPOP	0.8586	More...
P28702	Retinoic acid receptor RXR-beta	DEG_SPOP_SBC_1	83:87	PDSSS	SPOP	0.9539	More...

Showing 1 to 25 of 30 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSSS

Degron related mutations and impact score

Drug responses associated with ZNF335 mutations

All proteins holding degron of PDSSS