DegronMD - Q8TE77(SSH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A521V	TCGA-05-4410	LUAD	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.0833
p.A521V	DO25426	LUAD	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.0833
p.L105M	TCGA-2W-A8YY	CESC	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.25
p.L105M	DO223732	CESC	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.25
p.L543F	TCGA-86-8278	LUAD	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.1944
p.L543F	DO26308	LUAD	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.1944
p.S155I	TCGA-86-8358	LUAD	TCGA	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7341
p.S155I	DO25471	LUAD	ICGC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7341
p.S85Y	TCGA-A5-A0G1	UCEC	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation blocking phosphorylation signal	0.5278
p.S85Y	DO42472	UCEC	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation blocking phosphorylation signal	0.5278
p.G148V	TCGA-AB-2826	LAML	TCGA	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222
p.G148V	DO21833	LAML	ICGC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222
p.R531H	TCGA-AP-A1DO	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8244
p.R531H	TCGA-B5-A3FC	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8244
p.R531H	DO43250	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8244
p.R531H	DO41871	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8244
p.R529Q	TCGA-B5-A3FC	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.R529Q	DO41871	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.E143K	TCGA-DK-AA77	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.E143K	DO219014	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.R539G	TCGA-S9-A6TX	LGG	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.R539G	DO50184	LGG	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.T144M	TCGA-XF-A8HB	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.T144M	DO51907	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.T144M	DO52671	MALY	ICGC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.L100I	TCGA-XK-AAIW	PRAD	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6063
p.L100I	DO51407	PRAD	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.6063
p.S85F	DO48453	BLCA	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation blocking phosphorylation signal	0.5278
p.V537F	DO229031	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7068
p.R531L	DO229037	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8428
p.A521S	DO229045	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.0833
p.R95K	SIDM00417	Plasma Cell Myeloma	GDSC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.7237
p.R95K	U-266	haematopoietic and lymphoid tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.7237
p.Q89H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.Q89H	ACH-002059	Leukemia	CCLE	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.Q89H	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1944
p.M538I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6507
p.M538I	ACH-001362	Lung Cancer	CCLE	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6507
p.M538I	NCI-H1770	lung	COSMIC	PRINLRGVM	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6507
p.D110G	ACH-001719	Ovarian Cancer	CCLE	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1111
p.T101M	SLVL	haematopoietic and lymphoid tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.7423
p.T101M	NB1	autonomic ganglia	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.7423
p.S92C	VM-CUB-1	urinary tract	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.2778
p.Q152H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7582
p.A102D	CTV-1	haematopoietic and lymphoid tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation altering degron motif	0.7793
p.R151C	TE-15	oesophagus	COSMIC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.R166H	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PDSSS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0556
p.R110W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.1111
p.S92F	NCI-H2172	lung	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	94:102	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SSH3

UniProt ID: Q8TE77

Entrez ID: 54961

Protein name: Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SSH3 in