DegronMD

Uniprot ID: Q8TE77

Source protein: Protein phosphatase Slingshot homolog 3

Source gene: SSH3

Class: DEG_APCC_DBOX_1

Location: 530:538

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9606

ASA_SCORE: 74.2

COIL: 0.6969

CONS_SCORE: 0.361

DSS_SCORE: 0.5416

HELIX: 0.2098

FCONS_SCORE: 1.0159

RIG_SCORE: 0.722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A521V	TCGA-05-4410	LUAD	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.0833
p.A521V	DO25426	LUAD	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.0833
p.L543F	TCGA-86-8278	LUAD	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.1944
p.L543F	DO26308	LUAD	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.1944
p.R531H	TCGA-AP-A1DO	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.8244
p.R531H	TCGA-B5-A3FC	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.8244
p.R531H	DO43250	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.8244
p.R531H	DO41871	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.8244
p.R529Q	TCGA-B5-A3FC	UCEC	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.3056
p.R529Q	DO41871	UCEC	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.3056
p.R539G	TCGA-S9-A6TX	LGG	TCGA	PRINLRGVM	DEG_APCC_DBOX_1	0.3056
p.R539G	DO50184	LGG	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.3056
p.V537F	DO229031	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.7068
p.R531L	DO229037	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.8428
p.A521S	DO229045	LICA	ICGC	PRINLRGVM	DEG_APCC_DBOX_1	0.0833
p.M538I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PRINLRGVM	DEG_APCC_DBOX_1	0.6507
p.M538I	ACH-001362	Lung Cancer	CCLE	PRINLRGVM	DEG_APCC_DBOX_1	0.6507
p.M538I	NCI-H1770	lung	COSMIC	PRINLRGVM	DEG_APCC_DBOX_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_APCC_DBOX_1	530:538	PRINLRGVM	APC,CDC20,FZR1	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons