DegronMD

Uniprot ID: Q8TE77

Source protein: Protein phosphatase Slingshot homolog 3

Source gene: SSH3

Class: DEG_APCC_DBOX_1

Location: 94:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9624

ASA_SCORE: 53.5667

COIL: 0.0131

CONS_SCORE: 0.3593

DSS_SCORE: 0.5697

HELIX: 0.9856

FCONS_SCORE: 1.007

RIG_SCORE: 0.7497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L105M	TCGA-2W-A8YY	CESC	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	0.25
p.L105M	DO223732	CESC	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	0.25
p.S85Y	TCGA-A5-A0G1	UCEC	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	0.5278
p.S85Y	DO42472	UCEC	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	0.5278
p.L100I	TCGA-XK-AAIW	PRAD	TCGA	QRQHLHLMV	DEG_APCC_DBOX_1	0.6063
p.L100I	DO51407	PRAD	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	0.6063
p.S85F	DO48453	BLCA	ICGC	QRQHLHLMV	DEG_APCC_DBOX_1	0.5278
p.R95K	SIDM00417	Plasma Cell Myeloma	GDSC	QRQHLHLMV	DEG_APCC_DBOX_1	0.7237
p.R95K	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.7237
p.Q89H	SIDM00364	B-Lymphoblastic Leukemia	GDSC	QRQHLHLMV	DEG_APCC_DBOX_1	0.1944
p.Q89H	ACH-002059	Leukemia	CCLE	QRQHLHLMV	DEG_APCC_DBOX_1	0.1944
p.Q89H	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.1944
p.D110G	ACH-001719	Ovarian Cancer	CCLE	QRQHLHLMV	DEG_APCC_DBOX_1	0.1111
p.T101M	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.7423
p.T101M	NB1	autonomic_ganglia	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.7423
p.S92C	VM-CUB-1	urinary_tract	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.2778
p.A102D	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.7793
p.R110W	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.1111
p.S92F	NCI-H2172	lung	COSMIC	QRQHLHLMV	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TE77	Protein phosphatase Slingshot homolog 3	DEG_APCC_DBOX_1	94:102	QRQHLHLMV	APC,CDC20,FZR1	0.9624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons