DegronMD - Q92613(JADE3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S569I	TCGA-22-4613	LUSC	TCGA	PDSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7341
p.S18P	TCGA-28-1757	GBM	TCGA	PVSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1111
p.L151I	TCGA-43-7658	LUSC	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.1389
p.T558S	TCGA-49-AARQ	LUAD	TCGA	PDSSS	DEG_SPOP_SBC_1	567:571	Mutation blocking phosphorylation signal	0.5278
p.S570R	TCGA-53-7626	LUAD	TCGA	PDSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7427
p.H466Y	TCGA-55-1594	LUAD	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.0833
p.R468P	TCGA-A7-A6VX	BRCA	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1389
p.S572C	TCGA-AC-A23H	BRCA	TCGA	PDSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.D154Y	TCGA-AD-A5EJ	COAD	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.0556
p.E493D	TCGA-AN-A046	BRCA	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.0556
p.V135L	TCGA-BT-A20R	BLCA	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.3056
p.E493Q	TCGA-CQ-7071	HNSC	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.0556
p.M488I	TCGA-CR-7394	HNSC	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1944
p.E130K	TCGA-CV-A6K2	HNSC	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	136:144	Mutation rewiring degron network	0.1667
p.E15K	TCGA-D1-A17Q	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	6:10	Mutation rewiring degron network	0.1944
p.R3H	SIDM00377	Other Sarcomas	GDSC	PVSSS	DEG_SPOP_SBC_1	6:10	Mutation substituting flanking lysine	0.3611
p.R3H	SKN	soft tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	6:10	Mutation substituting flanking lysine	0.3611
p.L479M	SIDM00789	Colorectal Carcinoma	GDSC	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.711
p.L479M	HCT-15	large intestine	COSMIC	LRQDLERVR	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.711

Kaplan plot for JADE3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JADE3

UniProt ID: Q92613

Entrez ID: 9767

Protein name: Protein Jade-3 (Jade family PHD finger protein 3) (PHD finger protein 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JADE3 in