DegronMD

Uniprot ID: Q92613

Source protein: Protein Jade-3

Source gene: JADE3

Class: DEG_APCC_DBOX_1

Location: 475:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7814

ASA_SCORE: 50.5778

COIL: 0.0107

CONS_SCORE: 0.7687

DSS_SCORE: 0.1491

HELIX: 0.9889

FCONS_SCORE: 1.2532

RIG_SCORE: 0.8527

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H466Y	TCGA-55-1594	LUAD	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	0.0833
p.R468P	TCGA-A7-A6VX	BRCA	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	0.1389
p.E493D	TCGA-AN-A046	BRCA	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	0.0556
p.E493Q	TCGA-CQ-7071	HNSC	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	0.0556
p.M488I	TCGA-CR-7394	HNSC	TCGA	LRQDLERVR	DEG_APCC_DBOX_1	0.1944
p.L479M	SIDM00789	Colorectal Carcinoma	GDSC	LRQDLERVR	DEG_APCC_DBOX_1	0.711
p.L479M	HCT-15	large_intestine	COSMIC	LRQDLERVR	DEG_APCC_DBOX_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92613	Protein Jade-3	DEG_APCC_DBOX_1	475:483	LRQDLERVR	APC,CDC20,FZR1	0.7814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons