DegronMD

Uniprot ID: Q92613

Source protein: Protein Jade-3

Source gene: JADE3

Class: DEG_APCC_DBOX_1

Location: 136:144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7031

ASA_SCORE: 48.9333

COIL: 0.5042

CONS_SCORE: 0.6697

DSS_SCORE: 0.0465

HELIX: 0.395

FCONS_SCORE: 1.2169

RIG_SCORE: 0.9305

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L151I	TCGA-43-7658	LUSC	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	0.1389
p.D154Y	TCGA-AD-A5EJ	COAD	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	0.0556
p.V135L	TCGA-BT-A20R	BLCA	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	0.3056
p.E130K	TCGA-CV-A6K2	HNSC	TCGA	CRYDLDDMD	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92613	Protein Jade-3	DEG_APCC_DBOX_1	136:144	CRYDLDDMD	APC,CDC20,FZR1	0.7031	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons