DegronMD - Q15642(TRIP10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R354C	TCGA-06-5416	GBM	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.R354C	DO10880	GBM	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.E507Q	TCGA-66-2788	LUSC	TCGA	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.E507Q	DO26749	LUSC	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.R346W	TCGA-AD-6889	COAD	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.R346W	DO8463	COAD	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.G497R	TCGA-B5-A3FC	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.G497R	DO41871	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.R354H	TCGA-BS-A0UV	UCEC	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.R354H	DO42793	UCEC	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.3056
p.E357Q	TCGA-DK-A1AC	BLCA	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.6744
p.E357Q	DO514	BLCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.6744
p.Y493H	TCGA-FI-A2D0	UCEC	TCGA	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.Y493H	DO43891	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1944
p.E500K	TCGA-GD-A76B	BLCA	TCGA	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7022
p.E500K	DO51886	BLCA	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7022
p.S504C	DO228246	BRCA	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.D357N	DO222574	BTCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5821
p.V369L	DO8722	COAD	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.G348R	DO230322	COCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.Q349K	DO222465	ESCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.R353H	DO233245	GACA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.P508R	DO11100	GBM	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.R346L	DO228952	LICA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0833
p.C489F	DO229028	LICA	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0833
p.Q350L	DO50919	LICA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1944
p.R353S	DO52163	LIHC	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2778
p.M371T	DO232224	PBCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.P503S	DO41752	UCEC	ICGC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.A496T	SIDM01265	Plasma Cell Myeloma	GDSC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778
p.P492S	SIDM00529	Breast Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.P492S	SIDM00849	Kidney Carcinoma	GDSC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.S349F	COLO-792	skin	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.R356H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.8244
p.R356H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.8244
p.E371K	SNU-1040	large intestine	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.P504T	SW48	large intestine	COSMIC	PDSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2778

Kaplan plot for TRIP10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIP10

UniProt ID: Q15642

Entrez ID: 9322

Protein name: Cdc42-interacting protein 4 (Protein Felic) (Salt tolerant protein) (hSTP) (Thyroid receptor-interacting protein 10) (TR-interacting protein 10) (TRIP-10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIP10 in