DegronMD

Uniprot ID: Q15642

Source protein: Cdc42-interacting protein 4

Source gene: TRIP10

Class: DEG_APCC_DBOX_1

Location: 355:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9569

ASA_SCORE: 70.9778

COIL: 0.5577

CONS_SCORE: 0.2796

DSS_SCORE: 0.5709

HELIX: 0.3754

FCONS_SCORE: 1.0228

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R354C	TCGA-06-5416	GBM	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	0.3056
p.R354C	DO10880	GBM	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.3056
p.R346W	TCGA-AD-6889	COAD	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	0.0833
p.R346W	DO8463	COAD	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.0833
p.R354H	TCGA-BS-A0UV	UCEC	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	0.3056
p.R354H	DO42793	UCEC	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.3056
p.E357Q	TCGA-DK-A1AC	BLCA	TCGA	GRDPLAILS	DEG_APCC_DBOX_1	0.6744
p.E357Q	DO514	BLCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.6744
p.D357N	DO222574	BTCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.5821
p.V369L	DO8722	COAD	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.1667
p.G348R	DO230322	COCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.1389
p.Q349K	DO222465	ESCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.1667
p.R353H	DO233245	GACA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.2778
p.R346L	DO228952	LICA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.0833
p.Q350L	DO50919	LICA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.1944
p.R353S	DO52163	LIHC	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.2778
p.M371T	DO232224	PBCA	ICGC	GRDPLAILS	DEG_APCC_DBOX_1	0.1111
p.S349F	COLO-792	skin	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	0.1667
p.R356H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	0.8244
p.R356H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	0.8244
p.E371K	SNU-1040	large_intestine	COSMIC	GRDPLAILS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15642	Cdc42-interacting protein 4	DEG_APCC_DBOX_1	355:363	GRDPLAILS	APC,CDC20,FZR1	0.9569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons